Optimization of Various Grades of HPMC for Development of Sustained Release Matrix Tablets of Theophylline

Theophylline is a bronchodilator drug, used in treatment of asthma. The conventional dosage forms of Theophylline releases the entire drug in just few minutes and therefore the therapeutic concentrations will be maintained for a short period of time. This may leads to administration of subsequent dose. To overcome this, present study was aimed to develop the dosage form of Theophylline which will release the drug up to 12 hours. The matrix tablets of Theophylline were developed using different concentrations of various grades of HPMC and were evaluated for various pre-compression and post compression parameters. The data obtained was analyzed using linear model (Historical Data) of Design Expert 8.0.7.1(Trial version). Based on the results obtained, it was concluded that the Formulation F9 containing HPMC E15LV is suitable to develop sustained release matrix table of Theophylline which can release more than 50% drug in first 5 hours and more that 90% of the drug at the end of 9^th hour extended up to 12 hours.