Formulation and Characterization of fast Dissolving tablets of Perindopril

In this investigation fast dissolving tablets of perindopril were prepared using different superdisintegrants like sodium starch glycolate and crosspovidone by direct compression method. Fast dissolving drug delivery is fastest, safest, convenient and most economic method of drug delivery having the highest patient compliance and preferred over conventional tablets therefore it is currently the gold standard in the pharmaceutical industry. Formulations were evaluated for precompressional parameters bulk density, tapped density, cars index, angle of repose etc and postcompressional parameters like uniformity of weight, thickness, hardness, friability, drug content, wetting time, water absorption ratio, in vitro disintegration time and in vitro dissolution study. The formulation A1 to A3 contain increasing concentration of Sodium starch glycolate showed the increases dissolution rate of drug release from 92.75 to 98.25 in 15 min, whereas formulation B1 to B3 contain crosspovidone in increasing concentration also increases the drug release from 94.75 to 99.02 in 15 min. The drug release from FDTs increased with increasing concentration of superdisintegrants and was found to be highest with formulations containing Crosspovidone as compared to sodium starch glycolate.