Asian Journal of Pharmacy and Technology

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A Validated RP-HPLC Method for Simultaneous Estimation of Pseudoephedrine and Terfinadine in its Bulk and Pharmaceutical Dosage Forms


Affiliations
1 Department of Pharmaceutical Analysis, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, Andhra Pradesh, India
2 Chilkur Balaji College of Pharmacy, Aziz Nagar, Hyderabad, Telangana, India
3 Department of Pharmaceutical Analysis and QA, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad-500097, Telangana, India
4 Chaithanya College of Pharmacy, Markapur, Prakasham (Dist), A.P., India
     

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The present work deals with the development of a precise, accurate, simple, specific, reliable and less time consuming RP-HPLC method for the estimation of Pseudoephedrine and Terfinadine tablets .The chromatographic separation was achieved on a Inertsil C18 ODS (4.6×250 mm, 5 μm) with a mobile phase combination of methanol and water (50:50) v/v at a flow rate of 1.0 ml/min, and the detection was carried out by using PDA detector at 290 nm. Ambient column temperature has maintained. The total run time was 10mins.The retention time of Pseudoephedrine and Terfinadine were found to be 2.9 min. and 3.5 min. respectively. The performance of the method was validated according to the present ICH guidelines.

Keywords

RP-HPLC Method, Pseudoephedrine and Terfinadine, Tablet Dosage Forms, PDA Detection.
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  • A Validated RP-HPLC Method for Simultaneous Estimation of Pseudoephedrine and Terfinadine in its Bulk and Pharmaceutical Dosage Forms

Abstract Views: 322  |  PDF Views: 0

Authors

G. Kumaraswamy
Department of Pharmaceutical Analysis, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, Andhra Pradesh, India
Gandla Lalitha
Chilkur Balaji College of Pharmacy, Aziz Nagar, Hyderabad, Telangana, India
K. Swetha
Department of Pharmaceutical Analysis and QA, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad-500097, Telangana, India
R. Suthakaran
Department of Pharmaceutical Analysis and QA, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad-500097, Telangana, India
G. Ramesh Babu
Chaithanya College of Pharmacy, Markapur, Prakasham (Dist), A.P., India

Abstract


The present work deals with the development of a precise, accurate, simple, specific, reliable and less time consuming RP-HPLC method for the estimation of Pseudoephedrine and Terfinadine tablets .The chromatographic separation was achieved on a Inertsil C18 ODS (4.6×250 mm, 5 μm) with a mobile phase combination of methanol and water (50:50) v/v at a flow rate of 1.0 ml/min, and the detection was carried out by using PDA detector at 290 nm. Ambient column temperature has maintained. The total run time was 10mins.The retention time of Pseudoephedrine and Terfinadine were found to be 2.9 min. and 3.5 min. respectively. The performance of the method was validated according to the present ICH guidelines.

Keywords


RP-HPLC Method, Pseudoephedrine and Terfinadine, Tablet Dosage Forms, PDA Detection.