Asian Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Formulation and Evaluation of Oro Dispersible Tablets of Atenolol by Sublimation Method


Affiliations
1 Department of Pharmaceutics, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
2 Department of Pharmaceutics, Talla Padmavathi College of Pharmacy, karreeemabad Bodrai (V), Warangal (D), Telangana – 506012, India
3 Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
4 Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
     

   Subscribe/Renew Journal


The present study aims to formulate and evaluate oro dispersible tablets of Atenolol, a drug that is used for the treatment of chest pain (angina) was prepared by using sublimation method and also optimize the best formulation. The study involved different excipients which were tested for their compatibility with Atenolol by the FT-IR studies. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Atenolol which were used for the preparation of Atenolol oral disintegrating tablets. Oral disintegrating tablets of Atenolol were prepared by direct compression method by the addition of subliming agents. Twelve batches (H1-H12) of oral disintegrating tablets of Atenolol were prepared by using Subliming agents like Ammonium Carbonate, Camphor, Thymol and Menthol in variable concentrations along with other excipients for the development of optimized formulation. All the formulations were subjected to evaluation studies of weight variation, hardness, friability, drug content, Wetting time, in-vitro disintegration, in vitro-dissolution studies and are found to be within the limits.

Keywords

Oro Dispersible Tablet (ODT), Atenolol, Direct Compression, Sublimation Method, Anti Angina Activity.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Rangasamy Manivannan. Oral disintegrating tablets: A future Compaction Publication. International Journal of Pharmaceutical Research and Development 2009; 1: 1-10.

  • Ibrahim HK, El-Setouhy DA. Valsartan orodispersible tablets: formulation, in vitro/in vivo characterization. AAPS PharmSciTech 2010;11: 189-96.

  • Revathi S, Moulali SK, Dhanaraju MD. Formulation and evaluation of orodispersible valsartan tablets. Pharm Lett. 2015; 7: 315-24.

  • Rewar S, Singh C, Bansal B, Pareek R, Sharma A. Oral dispersible tablets: An overview; development, technologies and evaluation. Int J Res Dev Pharm Life Sci. 2014; 3: 1223-35.

  • Deshpande K, Ganesh N. Orodispersible tablets: an overview of formulation and technology. Int J Pharma Biol Sci. 2011; 2: 72634.

  • L Lachman, HA Liberman, Joseph L Kani G. The Theory and Practice of Industrial Pharmacy. Varghese publishing house. Bombay. 1990; 3rd Edition: p. 315-317.

  • Patel B, Patel JK, Rajput G, Thakor R. Formulation and evaluation of tablets of cinnarizine. Journal of pharmacy research. 2009; 2(3):510-13.

  • L Lachman, HA Liberman, Joseph L Kani G. The Theory and Practice of Industrial Pharmacy. Verghese Publication House. Bombay. 1990; 3rd Edition: p. 171-193.

  • Jeevanandham S , Dhachinamoorthi D, Chandrashekhar KB, Muthukumaran M, Sriram N. Formulation and evaluation of naproxen sodium orodispersible tablets- A sublimation technique. Asian journal of pharmaceutics. 2010; 4(1):48-51.


Abstract Views: 539

PDF Views: 1




  • Formulation and Evaluation of Oro Dispersible Tablets of Atenolol by Sublimation Method

Abstract Views: 539  |  PDF Views: 1

Authors

Nirmala Rangu
Department of Pharmaceutics, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
B. Chaitanya Kumari
Department of Pharmaceutics, Talla Padmavathi College of Pharmacy, karreeemabad Bodrai (V), Warangal (D), Telangana – 506012, India
Ganesh Akula
Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India
A. Jaswanth
Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, India

Abstract


The present study aims to formulate and evaluate oro dispersible tablets of Atenolol, a drug that is used for the treatment of chest pain (angina) was prepared by using sublimation method and also optimize the best formulation. The study involved different excipients which were tested for their compatibility with Atenolol by the FT-IR studies. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Atenolol which were used for the preparation of Atenolol oral disintegrating tablets. Oral disintegrating tablets of Atenolol were prepared by direct compression method by the addition of subliming agents. Twelve batches (H1-H12) of oral disintegrating tablets of Atenolol were prepared by using Subliming agents like Ammonium Carbonate, Camphor, Thymol and Menthol in variable concentrations along with other excipients for the development of optimized formulation. All the formulations were subjected to evaluation studies of weight variation, hardness, friability, drug content, Wetting time, in-vitro disintegration, in vitro-dissolution studies and are found to be within the limits.

Keywords


Oro Dispersible Tablet (ODT), Atenolol, Direct Compression, Sublimation Method, Anti Angina Activity.

References