Asian Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Prescription Analysis of Antiepileptic Drugs in a Tertiary Care Hospital


Affiliations
1 Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Elayampalayam - 637205, India
     

   Subscribe/Renew Journal


The objective of the study was to analyze the prescription pattern and drug related problems of antiepileptic drugs. The prospective descriptive study was carried out for a period of 6 months in a tertiary care hospital. The prescriptions were analyzed to identify the polypharmacy, adverse drug reactions and medication error. The patients were included in the study was with all type of epilepsy of both male and female patients with any age group of in and out patients. The identified medication error was categorized with the help of NCC MERP category. Causality assessment of adverse reaction was performed by the Naranjo algorithm. Analyzed the obtained prescription and identified the Polypharmacy in geriatric patients. Total 50 patients with 406 drugs, of these 6 Polypharmacy (12%), 7 medication error (16%) and 6 serious ADR were identified. The current study observed that the prescription contains drug-related problems were assessed to a greater extent and are comparable with the existing literature. Continued relationship with clinical pharmacist should be encouraged for better treatment option thereby improving the patient's quality of life effectively.

Keywords

Prescription, Epilepsy, Polypharmacy, Medication Error, Adverse Drug Reaction.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Roger Walker and Cate Whittlesea. Clinical Pharmacy and Therapeutics. 5th edition. Churchill Livingstone Elsevier. 2012; 489-490.

  • Leon Shargel, Alan H.Mutnick, Paul F. Souney, Larry N. Swanson. Comprehensive Pharmacy Review. 8th ed Lippincott Williams and Wilkins. 2014; 743-744.

  • WHO/Mediacentre/Epilepsy Fact Sheet February 2016. www.who.int/mediacentral factsheets/fs 999/en/.

  • Desak Ketut Ernawati, Ya Ping Lee, Jeffery David Hughes. Nature and Frequency of Medications Errors in a Geriatric Ward: An Indonesian experience. 2014; 10: 413-421.

  • Mark Anderson, Oluwaseun Egunsola, Janine Cherril, Clarie Milluard, Apostolos Fakis, Imti Choonara. A Prospective Study of Adverse drug reactions to Anti-epileptics drugs in Children. 2015; 5: 1-7.

  • McHugh JC, Delanty N. Epidemiology and Classification of Epilepsy: Gender Comparisons. 2008; 83: 11-26

  • Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked Seizures in Rochester, Minnesota: 1935-1984; 34: 453-468.

  • Theodore WH, Porter RJ, Albert P, Kelley K, Bromfield E, Devinsky O, Sato S. The secondarily Generalised Tonic Clonic seizures: a videotape analysis. 1994; 44: 1403-7.

  • Sudhir Kumar Vujhini, PanduRangaRaoSanagapati, Mahesh Kandukur. Drug induced hemolysis due to ceftriaxone: a case report of rare adverse reaction. 2014; 2: 25-27.

  • Robert Krysiak, Bogusław Okopień. A study on carbamazepine induced hyponatremia. 2007; 117: 193-195.

  • Franqois Caron, Philippe Ducrotte, Eric Lerebours, Raymond Colin, Guy Humbert, and Philippe Denis. A double-blind cross over study on effects of Amoxicillin Clavulanate combination on the motility of the small intestine in human beings. 1991; 35: 1085-1088.

  • W. A Stewart, R Harrison, J M Dooley. Respiratory depression in the acute management of seizures. 2002; 87: 225–226.

  • Gretchen. L. Johnson, Lynn Limon, Gita Trikha, Hillary Wall.Acute renal failure and neurotoxicity following Oral Acyclovir. 1994; 28: 460-463.

  • Choi YF, Wong TW, Lau CC. Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation, 2004; 21: 700–702.

  • A.P. Murphy, H. Bentur, C. Dolan, T. Bugembe, A. Gil, R. Appleton. Study on outpatient anti-epileptic drug prescribing errors in a children's hospital: an audit and literature review seizure. 2014; 23: 786-791.

  • Tania, Azevedo Anacleto, Edson Perini, Mário Borges Rosa, CibeleComini César. Drug dispensing errors in the hospital pharmacy. 2007; 62: 243-50.

  • Tamilselvan T, Veerapandiyan A K, Karthik N, Study on Drug Utilization Pattern of Chronic Renal Failure Patients in A Tertiary Care Hospital, International Journal of Pharmacy and Pharmaceutical Sciences, 2014; 6(9); 482-48.

  • Senatikish Amsalu Feleke, Muluadam Abebe Mulatu and Yeshaneh Seyoum Yesmaw, Medication administration error: magnitude and associated factors among nurses in Ethiopia. 2015; 14:1-8.


Abstract Views: 523

PDF Views: 1




  • Prescription Analysis of Antiepileptic Drugs in a Tertiary Care Hospital

Abstract Views: 523  |  PDF Views: 1

Authors

T. Tamilselvan
Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Elayampalayam - 637205, India
C. Arokia Rani
Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Elayampalayam - 637205, India
Ashna Raj
Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Elayampalayam - 637205, India
M. Leena Priya
Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Elayampalayam - 637205, India
Nissy Varghese
Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Elayampalayam - 637205, India
Sojan P. Paul
Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Elayampalayam - 637205, India

Abstract


The objective of the study was to analyze the prescription pattern and drug related problems of antiepileptic drugs. The prospective descriptive study was carried out for a period of 6 months in a tertiary care hospital. The prescriptions were analyzed to identify the polypharmacy, adverse drug reactions and medication error. The patients were included in the study was with all type of epilepsy of both male and female patients with any age group of in and out patients. The identified medication error was categorized with the help of NCC MERP category. Causality assessment of adverse reaction was performed by the Naranjo algorithm. Analyzed the obtained prescription and identified the Polypharmacy in geriatric patients. Total 50 patients with 406 drugs, of these 6 Polypharmacy (12%), 7 medication error (16%) and 6 serious ADR were identified. The current study observed that the prescription contains drug-related problems were assessed to a greater extent and are comparable with the existing literature. Continued relationship with clinical pharmacist should be encouraged for better treatment option thereby improving the patient's quality of life effectively.

Keywords


Prescription, Epilepsy, Polypharmacy, Medication Error, Adverse Drug Reaction.

References