Asian Journal of Pharmacy and Technology

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Preparation and Evaluation of Sustained Release Hydrogel Alginate Beads of Meclizine Hydrochloride


Affiliations
1 Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Pote Patil Road, Amravati – 444602 Maharashtra, India
     

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Oral controlled drug delivery systems represent the foremost widespread kind of sustained drug delivery systems for the plain blessings of oral route of drug administration. Suchsystemsrelease the drug with constant or variable unleash rates. The oral controlled releasesystems show a typical pattern of drug unleash within which the drug concentration is maintained inthe therapeutic window for a chronic amount of your time (sustained release), thereby guaranteeingsustained therapeutic action. They are used as single dosage form. Present work involvespreparation and analysis of sustained release beads of beads of Meclizine Hydrochloride using Sodium alginate as natural polymer as well as Hydroxyl Propyl Methyl Cellulose K15, Sodium CMC. The technique employed for preparation of beads of the drug is ionotropic gelation.

Keywords

Microbeads, Ionotropic Gelation, Natural Polymers, Sustained Release, HPMC-K15, Sodium CMC
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  • Preparation and Evaluation of Sustained Release Hydrogel Alginate Beads of Meclizine Hydrochloride

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Authors

Neha Deshmukh
Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Pote Patil Road, Amravati – 444602 Maharashtra, India

Abstract


Oral controlled drug delivery systems represent the foremost widespread kind of sustained drug delivery systems for the plain blessings of oral route of drug administration. Suchsystemsrelease the drug with constant or variable unleash rates. The oral controlled releasesystems show a typical pattern of drug unleash within which the drug concentration is maintained inthe therapeutic window for a chronic amount of your time (sustained release), thereby guaranteeingsustained therapeutic action. They are used as single dosage form. Present work involvespreparation and analysis of sustained release beads of beads of Meclizine Hydrochloride using Sodium alginate as natural polymer as well as Hydroxyl Propyl Methyl Cellulose K15, Sodium CMC. The technique employed for preparation of beads of the drug is ionotropic gelation.

Keywords


Microbeads, Ionotropic Gelation, Natural Polymers, Sustained Release, HPMC-K15, Sodium CMC

References