Asian Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

In-vitro, In-vivo Evaluation of Floating Tablets of Clarithromycin


Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India
2 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India
     

   Subscribe/Renew Journal


The main purpose of this research work was to design and process optimization of oral floating drug delivery system of Clarithromycin floating tablets by using the hydrophilic polymer Hydroxylpropyl methyl cellulose and gas generating agent sodium bicarbonate and citric acid. A 32 randomized full factorial design was used to study. In this design 2 factors were evaluated, each at 3 levels and experimental trials were performed at all 9 possible combinations. The independent and dependent variables are selected for optimization study. The radio-labelled floating tablets were prepared by adding barium sulphate in the optimized formulations for in- vivo radiographic study. The Results of multiple regression analysis indicated that both factors X1 and X2 significantly affected on the dependent parameters. The formulation was optimized on the basis of floating ability and in-vitro drug release. It should be concluded that as the time increases, the swelling index was increased, because weight gain by tablet was increased proportionally with rate of hydration. In-vivo radiographic studies of the optimized formulations were performed using New Zeal Albino rabbits by X-ray imaging technique. The in-vivo X-ray imaging and radiographic studies clearly indicated that the prepared optimized floating tablets were retained in the rabbit stomach over a prolonged period of time and had good in-vivo performance. Radiological evidences suggest that the formulated floating tablets of antibiotics were well floated more than 6 h in rabbit stomach.

Keywords

In-vivo Radiographic Studies, In-vivo Performance, New Zeal Albino Rabbits, Clarithromycin Floating Tablets
Subscription Login to verify subscription
User
Notifications
Font Size


  • Basak S.C., Rahman J., Ramalingam M. Design and in-vitro testing of a floatable gastroretentive tablet of metformin hydrochloride. Pharmazie. 2007; 62(2): 145-148.

  • Patel V. F., Patel N. M. Intragastric Floating Drug Delivery System of Cefuroxime Axetil: In Vitro Evaluation. AAPS Pharm. Sci. Tech. 2006; 7(1): 118-124.

  • Drug Bank: https://go.drugbank.com/salts/DBSALT002306.

  • Sonar G. S. Jain D. K. Preparation and in-vitro evaluation of bilayer and floating bioadhesive tablets of rosiglitazone meleate. J. Pharm. Sci. 2007; 2(4): 161-169.

  • Dave B. S., Amin A.F., Patel M.M. Gastroretentive Drug Delivery System of Ranitidine Hydrochloride: Formulation and In-Vitro Evaluation. AAPS Pharm. Sci. Tech. 2004; 5(2): 34-42.

  • Dalavi V. et al. Statistical Optimization and Development of Gastro Retentive of an Antiretroviral Drug using a 32 Factorial Design. Indian J. Pharm. Educ. Res. 2010; (3): 44.

  • Basak S.C, Rao N. Development and in-vitro evaluation of an oral floating matrix tablet formulation of ciprofloxacin. Indian J. Pharm. Sci. 2004; 66(3): 313-316.

  • Gambhire M. N. Development and in-vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride. AAPS Pharm. Sci. Tech. 2007; 8(3): E1-E9.

  • Patel V. F., Patel N. M. Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets. Drug Dev. Ind. Pharm. 2007; 33(3): 327-334.

  • Anilkumar J. Shinde, Arun N. Waghule, Manoj B. Paithane, Harinath N. More. Formulation and in-vitro evaluation of sustained release floating tablet of cephalexin using hydrophilic polymers. Int. J. Pharm. Sci. 2010; 2(2):58-65.

  • Martindale, the Complete Drug Reference. Sweetman Sean C., Blake P. S. 34th Edition Pharmaceutical Press London. 2005; 192-193, 155-156 and 168.

  • Sutar R., Masareddy R. et al. hydrodynamically balanced tablets of Clarithromycin. Res. J. Pharma. Biol. Chem. Sci. 2010; 1(3): 284.

  • Putta R. K., Hiremath D. et al. Design and evaluation studies on novel floating tablets for peptic ulcer treatment. J. Adv. Pharm. Edu. Res. 2011; 2: 159-176.

  • Singh P. K., Kumar S. et al. Formulation Development and Evaluation of Clarithromycin oral Dosage form. Int. Res. J. Pharm. 2012; 3(4): 281-287.

  • Prajapati S. T. et al. Floating matrix tablets of domperidone: Formulation and optimization using simplex lattice design. Thai. J. Pharm. Sci. 2009; 33: 113-122.

  • Santha Sheela N. B., Damodharan N. Formulation and Evaluation of Clarithromycin Gastroretentive dosage form. Int. J. Pharm. Pharma. Sci. 2010; 2(3): 48-55.


Abstract Views: 126

PDF Views: 0




  • In-vitro, In-vivo Evaluation of Floating Tablets of Clarithromycin

Abstract Views: 126  |  PDF Views: 0

Authors

Manojkumar Patil
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India
Audumbar Mali
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India
Sunayana Mali
Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India

Abstract


The main purpose of this research work was to design and process optimization of oral floating drug delivery system of Clarithromycin floating tablets by using the hydrophilic polymer Hydroxylpropyl methyl cellulose and gas generating agent sodium bicarbonate and citric acid. A 32 randomized full factorial design was used to study. In this design 2 factors were evaluated, each at 3 levels and experimental trials were performed at all 9 possible combinations. The independent and dependent variables are selected for optimization study. The radio-labelled floating tablets were prepared by adding barium sulphate in the optimized formulations for in- vivo radiographic study. The Results of multiple regression analysis indicated that both factors X1 and X2 significantly affected on the dependent parameters. The formulation was optimized on the basis of floating ability and in-vitro drug release. It should be concluded that as the time increases, the swelling index was increased, because weight gain by tablet was increased proportionally with rate of hydration. In-vivo radiographic studies of the optimized formulations were performed using New Zeal Albino rabbits by X-ray imaging technique. The in-vivo X-ray imaging and radiographic studies clearly indicated that the prepared optimized floating tablets were retained in the rabbit stomach over a prolonged period of time and had good in-vivo performance. Radiological evidences suggest that the formulated floating tablets of antibiotics were well floated more than 6 h in rabbit stomach.

Keywords


In-vivo Radiographic Studies, In-vivo Performance, New Zeal Albino Rabbits, Clarithromycin Floating Tablets

References