Asian Journal of Pharmacy and Technology

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Optimization of Oxiconazole Topical Emulgel Formulation for the Treatment of Skin Infections


Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
     

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Emulgel is one of the promising topical drug delivery system for the delivery of hydrophobic drugs which overcome a variety of disadvantages of ointments and creams like greasiness as well as phase inversion. The aim of present work was to develop and evaluate Oxiconazole emulgel. Oxiconazole emulgel was prepared by using polymers like Carbopol 934 and HPMC K4M at different concentrations. Oxiconazole is a broad spectrum anti - fungal agent used in treat of various skin infections such as athlete’s foot, jock itch and ring worm. The prepared emulgels were evaluated in terms of physical appearance, measurement of pH, viscosity, spreadability, drug content and in vitro diffusion studies and skin irritation study. Formulation F1 containing carbapol 934 is considered as optimized formulation because it showed highest drug release i.e., 58.57% in 8 hrs.

Keywords

Topical Drug Delivery, Emulgel, Oxiconazole, Carbapol 934, HPMC K4M, In Vitro Diffusion Studies
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  • Optimization of Oxiconazole Topical Emulgel Formulation for the Treatment of Skin Infections

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Authors

B. Hemalatha
Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
T. Pavani Priya
Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
K. Manasa
Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
Ch. Greeshmika
Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
P. Kavya
Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
Shaik Sayeeda Sarah
Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India
K. Padmalatha
Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India

Abstract


Emulgel is one of the promising topical drug delivery system for the delivery of hydrophobic drugs which overcome a variety of disadvantages of ointments and creams like greasiness as well as phase inversion. The aim of present work was to develop and evaluate Oxiconazole emulgel. Oxiconazole emulgel was prepared by using polymers like Carbopol 934 and HPMC K4M at different concentrations. Oxiconazole is a broad spectrum anti - fungal agent used in treat of various skin infections such as athlete’s foot, jock itch and ring worm. The prepared emulgels were evaluated in terms of physical appearance, measurement of pH, viscosity, spreadability, drug content and in vitro diffusion studies and skin irritation study. Formulation F1 containing carbapol 934 is considered as optimized formulation because it showed highest drug release i.e., 58.57% in 8 hrs.

Keywords


Topical Drug Delivery, Emulgel, Oxiconazole, Carbapol 934, HPMC K4M, In Vitro Diffusion Studies

References