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An Overview on Mini Tablets


Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, India
2 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, India
     

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Mini Tablets are solid dosage forms with a diameter <= 3 mm and separated into subunits of conventional tablets. Production methods are similar to standard tablets, but the only difference is the use of multiple punches. They have advantageous for use in patients suffering from swallowing difficulty and receiving multiple drug treatment. They provide a more effective treatment by reducing the fluctuation in the drug’s release profile. At the same time, different release systems can be used together. In addition, Mini Tablets have a number of advantages over single unit dosage forms, and in recent years the prominence continues to increase. In the light of this information, the advantages and disadvantages of mini tablets, production equipment, formulation designs, different emission characteristics and evaluation criteria are emphasized in this compilation. Mini tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less.

Keywords

Mini Tablets, Solid Dosage Form, Oral Drug Delivery, Sustained Release
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  • Hellebechgaard and gydahegermannnielsen. Controlled-release multiple-units and single-unit doses a literature review. Drug Development and Industrial Pharmacy, 1978; 4(1): 53-67.
  • Lennartz P., Mielck J. B. Mini tabletting: improving the compactability of paracetamol powder mixtures. International Journal of Pharmaceutics 1998; 173(1): 75-85.
  • Ghebre-Sellasie I, Multi particulate oral drug delivery, Marcel Dekker, Drugs and the Pharmaceutical Sciences, Taylor and Francis, New York. 1994; 65: 307-312.
  • Mohd Abdul Hadi, Raghavendra Rao NG, Novel Techniques in Formulations: An Overview. World Journal of Pharmaceutical Research. 2012; 1(3): 1-17.
  • Schmidt C, Kleinebudde P, Influence of the granulation step on pellets prepared by extrusion/spheronization, Chem. Pharm, Bull. 1999; 47(3): 405-412.
  • Gupta Swati, Singh Sushma, Multiple Unit System: An Approach towards Gastro retention. Journal of Biological and Scientific Opinion. 2014; 2(2): 188-195.
  • Lopes C. M., Lobo J. M. S., Pinto J. F., Costa P. Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release. Drug Dev. Ind. Pharm. 2006; 32: 95-106.
  • Modi S. A., Gaikwad P. D., Bankar V. H., Pawar S. P. Sustained release drug delivery system: a review. International Journal of Pharma Research and Development. 2011; 11: 147-198. 10
  • Raghavendra Rao N. G., Mohd Abdul Hadi, Harsh Panchal. A Novel approach to sustained Montelukast sodium release: Differentially coated mini-tablets in HPMC capsules. International Journal of Pharmaceutical and Biomedical Sciences. 2011; 2(2): 90-97.
  • Karthikeyan D., Vijayalaxmi A., Santhosh Kumar C. Formulation and evaluation of biphasic Delivery system of Aceclofenac mini- tablets in hard gelatin capsules. International Journal of Novel Trends in Pharmaceutical Sciences. 2013; 3(2):39-45.
  • Solanki B., Patel R., Barot B., Parejiya P., Shelat P. Multiple Unit Dosage Forms: A Review, Pharmtechmedica. 2012; 1(1): 11-21
  • Mirelabodea, Ioantomuţă, Sorinleucuţa. Identification of Critical Formulation Variables for Obtaining Metoprolol Tartrate Mini-tablets. Farmacia. 2010; 58: 719-727.
  • Chauhan V., Kumar K., Teotia D. Fast dissolving tablets: a promising approach for drug delivery. Univ. J. Pharm. Res. 2017; 2(4): 58-64.
  • Garg D, Saini V., Gupta S., Kapoor D. N., Joshi L. Controlled-release multiple-units and single-unit doses a literature review. International Journal of Pharmaceutical Sciences. 2013; 4(2): 66-73.
  • Robert S. Rosenson Low high-density lipoprotein cholesterol and cardiovascular disease: Risk reduction with statin therapy. American Heart Journal. 2006; 151(3): 556-56.
  • Mali A. D., Bathe R. S. Design and optimization of gastro retentive floating matrix tablets of an antihypertensive drug Quinapril HCl. Int. J. Pharm. Technol. 2015; 7: 9212-9224.
  • Mali A. D., Bathe R. S. A review on gastro retentive floating drug delivery system. Ame. J. Pharm. Tech. Res. 2015; 5: 107-32.
  • A. D. Mali, R. S. Bathe. Development and evaluation of gastroretentive floating tablets of a Quinapril HCl by direct compression technique. Int. J. Pharm. Pharm. Sci. 2017; 9(8): 35-46.

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  • An Overview on Mini Tablets

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Authors

Shubhangi Kodag
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, India
Swaranjali Gaikwad
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, India
Sunayana Mali
Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, India
Audumbar Mali
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, India

Abstract


Mini Tablets are solid dosage forms with a diameter <= 3 mm and separated into subunits of conventional tablets. Production methods are similar to standard tablets, but the only difference is the use of multiple punches. They have advantageous for use in patients suffering from swallowing difficulty and receiving multiple drug treatment. They provide a more effective treatment by reducing the fluctuation in the drug’s release profile. At the same time, different release systems can be used together. In addition, Mini Tablets have a number of advantages over single unit dosage forms, and in recent years the prominence continues to increase. In the light of this information, the advantages and disadvantages of mini tablets, production equipment, formulation designs, different emission characteristics and evaluation criteria are emphasized in this compilation. Mini tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less.

Keywords


Mini Tablets, Solid Dosage Form, Oral Drug Delivery, Sustained Release

References