Asian Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Development of Topical Nanogel as a Promising Delivery of NSAID’s Tenoxicam using Natural Permeation Enhancer Essential Oil (Euckolyptus)


Affiliations
1 Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Dist. Kolhapur, Maharashtra, 416114, India
2 Annasaheb Dange College of B. Pharmacy, Ashta, Dist. Sangli, Maharashtra, 416 301, India
     

   Subscribe/Renew Journal


Tenoxicam (TNX) is an effective non-steroidal anti-inflammatory drug (NSAIDs) used to treat rheumatoid arthritis. Like other NSAIDs, tenoxicam has the disadvantage of being linked to gastrointestinal side effects. Furthermore, this drug is having weak transdermal penetration, preventing transdermal administration. The goal of this study was to develop a TNX nanogel with a smaller particle size to improve the anti-inflammatory drug's bioavailability and assess its potential in rheumatoid arthritis. The modified emulsification-diffusion method is used to develop nanosized dispersion of TNX using noveon polycarbophil AA-1 as a gelling agent. Moreover, essential oils increase skin penetration by interacting with the stratum corneum (SC). They were found to be successful in increasing skin penetration of both lipophilic and hydrophilic drugs. The rheology, particle size, drug content, % drug release, and in-vitro diffusion study of prepared TNX nanogel were performed. Based on the rheological features of the formulations it was found to be substantial, with the particle size of 125.05nm and zeta potential -8.47mV, drug content of 97.05%, % drug release 97.40% drug diffusion of 97.42%, and pH of 6.2. Tenoxicam nanogel was prepared by using noveon polycarbophil AA-1 and eucalyptus oil as a permeation enhancer was proven to be suitable as a typical topical gel formulation for the treatment of edema and rheumatoid arthritis.

Keywords

Artificial Membrane, Eucalyptus Oil, Nanogel, Noveon Polycarbophil AA-1, Tenoxicam, TDDS
Subscription Login to verify subscription
User
Notifications
Font Size


  • Meek I.L.; Van de Laar A.F.J.M.; Vonkeman.H.E: Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks, Pharmaceuticals (Basel). 2010 Jul; 3(7): 2146–2162.

  • Demiralay E.C.; Yılmaz H: Potentiometric pKa Determination of Piroxicam and Tenoxicam in Acetonitrile-Water Binary Mixtures; SDU Journal of Science (E-Journal), 2012, 7 (1):34-44.

  • Mundada M.S.; Wankhede S: Formulation and Evaluation of Topical gel Lornoxicam using a range of penetration Enhancer; Ind J. Pharm. Edu Res;Apr-Jun,2013/Vol.47/Issue 2; 168-171.

  • Reddy D.; Trost L.W.; Lee T.; Baluch A.R.; Kaye A.D: Rheumatoid Arthritis: Current Pharmacologic Treatment and Anesthetic Considerations.

  • Ammara H.O.; Ghorabb M.; El-Nahhasc S.E.; Higazya I.M: Proniosomes as a carrier system for transdermal delivery of tenoxicam, Int Jou. of Pharm. 405 (2011) 142–152.

  • Negi L. M.; Chauhan M: Nano-appended transdermal gel of Tenoxicam via ultradeformable drug carrier system. Journal of Experimental Nanoscience. Volume (8)2013:657-669.

  • Devi V.K.; Jain N.; Valli K.S: Importance of novel drug delivery systems in herbal medicines; Pharmacogn. Rev. 2010 Jan-Jun; 4(7): 27–31.

  • Martin G.P; Stuart A. Jones S.A; Akomeah F.K: Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects; Taylor & Francis; Drug Delivery, 13:175–187, 2006; ISSN: 1071-7544 print / 1521-0464.

  • Phatak A.A; Chaudhari P.D: Development and evaluation of Nanogel carrier for transdermal delivery of Aceclofenac; Asian J.pharm.Tech.2012; Vol.2: Issue 4; 125132.

  • Dhawal D: Nanogel as novel and versatile Pharmaceuticals; Int.J pharm Sci, Vol 4, Issue 3, 2012; 67-74.

  • Divya L; Ravichandiran S: Nanogels - as a drug delivery carrier. Indo American Journal of Pharm Research.2013:3(9)7356-7370.

  • Jithan A.V; M. Swati: Development of Topical Diclofenac sodium Liposomal Gel for Better Anti-inflammatory activity; Int.J.Pharm.Sci. Nanotech, Vol 3; Issue 2, July-Sept 2010; 986-993.

  • Alexander V.K; Serguei.V.Vinogradov: Nanogels as pharmaceutical carriers: finite networks of infinite capabilities, Angew.Chem.Int. Ed, 2009, 48:5418–5429.

  • Chauhan M; Negi L. M: Nano-appended transdermal gel of Tenoxicam via ultradeformable drug carrier system; journal of experimental nanoscience; volume (8)2013:657-669.

  • Avasatthi V; Chander P. D; Bansode P: A novel nanogel formulation of Tenoxicam for topical treatment of psoriasis: optimization, in vitro and in vivo evaluation. Pharmaceutical Development and Technology, 2015; 1-9.

  • Gupta G; Gaud R. S: Anti-inflammatory nanogel. Indian Journal of Pharmaceutical Sciences.2006, 68(3)356-359.

  • Reuben T. Chacco, Jiaming Zhuang; Thayumanavan S: Polymer nanogels: A versatile nanoscopic drug delivery platform. Advanced Drug Delivery Review, 2012, 64:836-851.

  • Koen R; Joseph De and Stefaan De Smedt: Advanced nanogel engineering for drug delivery. Soft Matter. 2009:707-715.

  • Amal J. Sivaram, P.Rajitha, S.Maya, R.Jayakumar and M.Sabitha: Nanogels for Delivery, Imaging and Therapy, 2015, 7(4):509-533.

  • Eckmann D; Composto R; A. Muzykantov V: Nanogel carrier design for targeted drug delivery, Journal of Materials Chemistry B, 2014, 2:1-13.

  • Gupta R; Gupta G.D: Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia obliqua Topical Gel on Animal Model; Pharmacogn J. 2017; 9(6) Suppl: s93-s98.

  • Chippada S.C; Sharan Suresh Volluri S.S; Bammidi S.R: In vitro anti inflammatory activity of methanolic extract of centella asiatica by HRBC membrane stabilization; Rasayan.j.Chem; Vol.4, No.2 (2011), 457-460; ISSN: 0974-1496.

  • Pant K; Kshitij A; Prem S: To study in vitro anti-inflammatory activity of Anthracephalus cadamba leaves extract; DHR Int. Jour.Pharm. Sci. (DHR-IJPS) ISSN: 2278-8328, Vol. 3(1), 2012.

  • Aiyalu R; Govindarjan A; Ramasamy A: Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model; Brazilian Journal of Pharm. Sci. vol. 52, n. 3, jul./sep., 2016.

  • Yvonne M. C. B; Arlene F. C; Rhoda B. M; Chad R. L. R; Riel A.T: Anti-inflammatory Property of the Formulated Topical Gel from the Crude Leaf Extracts of Sampaguita (Jasminum sambac L. Family: Oleaceae); Int. Jou. Chem. Eng. & Appl; Vol. 7, No. 3, June 2016.

  • Mundada M.S; Wankhede S: Formulation and Evaluation of Topical gel Lornoxicam using a range of penetration Enhancer; Ind J. Pharm. Edu Res; Apr-Jun,2013/Vol.47/Issue 2; 168-171.

  • Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J. Formulation develop¬ment, optimization and evaluation of Aloe Vera gel for wound healing. Pharmacognosy Mag. 2013; 9 (1):S6-S10


Abstract Views: 99

PDF Views: 0




  • Development of Topical Nanogel as a Promising Delivery of NSAID’s Tenoxicam using Natural Permeation Enhancer Essential Oil (Euckolyptus)

Abstract Views: 99  |  PDF Views: 0

Authors

Swapnil S. Chopade
Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Dist. Kolhapur, Maharashtra, 416114, India
Esther Gaikwad
Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Dist. Kolhapur, Maharashtra, 416114, India
Nikhil Patil
Annasaheb Dange College of B. Pharmacy, Ashta, Dist. Sangli, Maharashtra, 416 301, India
Arehalli Manjappa
Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Dist. Kolhapur, Maharashtra, 416114, India
John Disouza
Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Dist. Kolhapur, Maharashtra, 416114, India

Abstract


Tenoxicam (TNX) is an effective non-steroidal anti-inflammatory drug (NSAIDs) used to treat rheumatoid arthritis. Like other NSAIDs, tenoxicam has the disadvantage of being linked to gastrointestinal side effects. Furthermore, this drug is having weak transdermal penetration, preventing transdermal administration. The goal of this study was to develop a TNX nanogel with a smaller particle size to improve the anti-inflammatory drug's bioavailability and assess its potential in rheumatoid arthritis. The modified emulsification-diffusion method is used to develop nanosized dispersion of TNX using noveon polycarbophil AA-1 as a gelling agent. Moreover, essential oils increase skin penetration by interacting with the stratum corneum (SC). They were found to be successful in increasing skin penetration of both lipophilic and hydrophilic drugs. The rheology, particle size, drug content, % drug release, and in-vitro diffusion study of prepared TNX nanogel were performed. Based on the rheological features of the formulations it was found to be substantial, with the particle size of 125.05nm and zeta potential -8.47mV, drug content of 97.05%, % drug release 97.40% drug diffusion of 97.42%, and pH of 6.2. Tenoxicam nanogel was prepared by using noveon polycarbophil AA-1 and eucalyptus oil as a permeation enhancer was proven to be suitable as a typical topical gel formulation for the treatment of edema and rheumatoid arthritis.

Keywords


Artificial Membrane, Eucalyptus Oil, Nanogel, Noveon Polycarbophil AA-1, Tenoxicam, TDDS

References