Asian Journal of Pharmacy and Technology

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Formulation and Evaluation of Solid Dispersion of Poorly Soluble Drugs


Affiliations
1 Annasaheb Dange College of Pharmacy, Ashta, Maharashtra, India
2 Tatyasaheb Kore College of Pharmacy, Warananagar, Maharashtra, India
3 Alard College of Pharmacy, Pune, Maharashtra, India
4 Assistant Professor, Department of Pharmaceutics, Yashwantrao Bhonsale College of Pharmacy, Sawantwadi, Maharashtra, India
     

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Solid dispersion is one of the method, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersion based on the concept that the drug is dispersed in an inert water- soluble carrier at solid state. Several water-soluble carriers such as methyl cellulose, urea, lactose, citric acid, polyvinyl pyrrolidone and HPMC, cyclodextrin, polyethylene glycols 4000 and 6000 are used as carriers for solid dispersion. In the current research work, the solid dispersion technique can be successfully used for the improvement of dissolution of piperine and sulfamethaoxazole. In this regards, solid dispersions of these drugs were prepared by using HPMC E 100 and 2-Hydroxyproplyl beta cyclodextrin as a carrier in 1:1 ratio by solvent evaporation method. The saturation solubility and in-vitro dissolution studies of prepared solid dispersions were examined against pure piperine and sulfamethaoxazole. Faster dissolution was exhibited by piperine-2 hydroxypropyl beta cyclodextrin solid dispersion containing 1:1 ratio.

Keywords

Piperine, Sulfamethaxazole, Solid Dispersion, Poorly Soluble Drug, Solibility Enhancement etc.
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  • Lakshimi Narasaiah.V, Kalyan Reddy.B, Raj Kumar.M, Kiran Kumar. A Improved dissolution rate of atorvastatin calcium using solid dispersions with PEG-4000. J.Chem. Pharm.Res. 2010; 2(3):304-311.

  • Bore.K.R, Subrahmanya.C.R, Sarasija Suresh, Gaikwad.D.T, Patil.M.D. Formulation and evaluation of solid dispersion of atorvastatin with various carriers Pharmacies global. IJCP. 2011;1(2).

  • D.A. Alderman, A review of cellulose ethers in hydrophilic matrices for oral controlled- release dosage forms, Int. J. Pharm. Technol. Prod. Manuf. 1984; 5: 1-9.

  • Shin Etsu, Pharmacoat, Cellulose and pharmaceutical excipient department, 2004.

  • Karnik Priyanka. A, Mujawar Nigar. K, Nitave Sachin. A, Formulation and evolutions of solid dispersion of Lansoprazole. Indian Journal of Drug. 2016, 4(4), 183-192.

  • Carina Dahlberg, Drug and Polymer in Dissolving Solid dispersion: NMR Imaging and Spectroscopy, 2010

  • Yanbin Huang, Wei-Guo Dai. Fundamental aspect of solid dispersion technology for poorly soluble drugs, Acta Pharmaceutical Sinica B. 2014; 4(1):18-25.

  • Chau Le-Ngoc Vo, Chulhun Park, Beon-Jin Lee, Current trends and future perspectives of solid dispersion containing poorly water- soluble drugs. Europen Jouranal of Pharmaceutics. 2013; 85:799-813.

  • R. Santosh Kumar, Annu Kumari. Preparation and evaluation of Sulfamethaoxazole solid dispersion employing starch citrate-a-new solubility enhancer. Journal of Drug Delivery and Therapeutic. 2019; 9(2-s):237-242,

  • Rayapolu Ranga Goud, Gunnala Krishnaveni, Girija Prasad Patro. Solubility and bioavailability enhancement strategies for effective delivery of poorly water-soluble drug by nano formulations and solid Dispersions. IAJPS 2018, 05(02), 1028-1034.


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  • Formulation and Evaluation of Solid Dispersion of Poorly Soluble Drugs

Abstract Views: 73  |  PDF Views: 0

Authors

Komal Chandrakant Jadhav
Annasaheb Dange College of Pharmacy, Ashta, Maharashtra, India
Sourabh Sukumar Hegaje
Tatyasaheb Kore College of Pharmacy, Warananagar, Maharashtra, India
Sadhana Uttam Jadhav
Alard College of Pharmacy, Pune, Maharashtra, India
Rupesh Sopanrao Vaidhya
Alard College of Pharmacy, Pune, Maharashtra, India
Mayuresh Ramesh Redkar
Assistant Professor, Department of Pharmaceutics, Yashwantrao Bhonsale College of Pharmacy, Sawantwadi, Maharashtra, India

Abstract


Solid dispersion is one of the method, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersion based on the concept that the drug is dispersed in an inert water- soluble carrier at solid state. Several water-soluble carriers such as methyl cellulose, urea, lactose, citric acid, polyvinyl pyrrolidone and HPMC, cyclodextrin, polyethylene glycols 4000 and 6000 are used as carriers for solid dispersion. In the current research work, the solid dispersion technique can be successfully used for the improvement of dissolution of piperine and sulfamethaoxazole. In this regards, solid dispersions of these drugs were prepared by using HPMC E 100 and 2-Hydroxyproplyl beta cyclodextrin as a carrier in 1:1 ratio by solvent evaporation method. The saturation solubility and in-vitro dissolution studies of prepared solid dispersions were examined against pure piperine and sulfamethaoxazole. Faster dissolution was exhibited by piperine-2 hydroxypropyl beta cyclodextrin solid dispersion containing 1:1 ratio.

Keywords


Piperine, Sulfamethaxazole, Solid Dispersion, Poorly Soluble Drug, Solibility Enhancement etc.

References