Asian Journal of Pharmacy and Technology

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Study on Taste Masking of Ranitidine HCl Using Ion Exchange Resin


Affiliations
1 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India
2 College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.) India, India
3 School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), India
     

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The taste of a drug plays an important role in patient compliance. Ranitidine HCl is a Histamine blocker drug with bitter taste. The drug Ranitidine HCl was treated with a cation exchange resin, which forms complex with the drug and mask the bitterness of Ranitidine HCl. The loading process was optimized for the resin type, pH of loading solution and drug:resin ratio. The resin-drug complex was evaluated for taste by panel method. The rate of dissolution was studied and the drug had showed good release. These findings can be utilized to formulate a non bitter dosage form for Ranitidine HCl with good bioavailability.

Keywords

Ranitidine HCl, Ion Exchange Resin, Taste Masking, Resinates
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  • Study on Taste Masking of Ranitidine HCl Using Ion Exchange Resin

Abstract Views: 398  |  PDF Views: 2

Authors

Shiv Kumar Gupta
College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.), India
Babita Kumar
College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.) India, India
Pramod Kumar Sharma
School of Pharmacy, Galghotia University, Greater Noida, G B Nagar, (U. P.), India

Abstract


The taste of a drug plays an important role in patient compliance. Ranitidine HCl is a Histamine blocker drug with bitter taste. The drug Ranitidine HCl was treated with a cation exchange resin, which forms complex with the drug and mask the bitterness of Ranitidine HCl. The loading process was optimized for the resin type, pH of loading solution and drug:resin ratio. The resin-drug complex was evaluated for taste by panel method. The rate of dissolution was studied and the drug had showed good release. These findings can be utilized to formulate a non bitter dosage form for Ranitidine HCl with good bioavailability.

Keywords


Ranitidine HCl, Ion Exchange Resin, Taste Masking, Resinates

References