Asian Journal of Pharmacy and Technology

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Investigation of Antiepileptic Activity of Hibiscus vitifolius Leaves


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1 SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India
     

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The leaves of Hibiscus vitifolius (Malvaceae) for the present studies was selected on the basis of literature review. The fresh leaves were collected from Thakur Chhedilal barrister Agriculture College and Research Centre, Bilaspur, Chhattisgarh. The Plant material was authenticated by Dr. H. B. Singh. Ref No. is NISCAIR/RHMD/Consult/-2011- 12/1868/168 on 24 Oct 2011 New Delhi. Shade dried leaves were powdered in a hand grinder and extracts were prepared in chloroform and ethanol solvents. Phytochemical studies found that the presence of flavionoids, glycosids, Sterols, Fatty acids and carbohydrate. Acute oral toxicity study of plant extracts was conducted in mice by using OECD guideline no.425 and it was found to safe up to the dose label of 6000mg/kg of body weight. In Maximal electro-shock (MES) induced model, dose of EEHV (200, 400 and 600 mg/kg) show significant anticonvulsant activity, but dose of chloroform extract of Hibiscus vitifolius (CEHV) did not show any anticonvulsant activity as compared to control group. In Pentylenetetrazol (PTZ) model lower dose of EEHV (200, 400 and 600 mg/kg) show good anticonvulsant activity as compared to control group. Locomotor study in actophotomotor extract of EEHV exhibited the decreased motor activity in dose dependent manner, it is sign of sedation. EEHV increase the threshold of MES induced convulsion in a dose dependent manner.

Keywords

Hibiscus vitifolius, PTZ, Maximal electro-shock, Diazepam and Phenytoin
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  • Investigation of Antiepileptic Activity of Hibiscus vitifolius Leaves

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Authors

Pradeep Kumar Samal
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

Abstract


The leaves of Hibiscus vitifolius (Malvaceae) for the present studies was selected on the basis of literature review. The fresh leaves were collected from Thakur Chhedilal barrister Agriculture College and Research Centre, Bilaspur, Chhattisgarh. The Plant material was authenticated by Dr. H. B. Singh. Ref No. is NISCAIR/RHMD/Consult/-2011- 12/1868/168 on 24 Oct 2011 New Delhi. Shade dried leaves were powdered in a hand grinder and extracts were prepared in chloroform and ethanol solvents. Phytochemical studies found that the presence of flavionoids, glycosids, Sterols, Fatty acids and carbohydrate. Acute oral toxicity study of plant extracts was conducted in mice by using OECD guideline no.425 and it was found to safe up to the dose label of 6000mg/kg of body weight. In Maximal electro-shock (MES) induced model, dose of EEHV (200, 400 and 600 mg/kg) show significant anticonvulsant activity, but dose of chloroform extract of Hibiscus vitifolius (CEHV) did not show any anticonvulsant activity as compared to control group. In Pentylenetetrazol (PTZ) model lower dose of EEHV (200, 400 and 600 mg/kg) show good anticonvulsant activity as compared to control group. Locomotor study in actophotomotor extract of EEHV exhibited the decreased motor activity in dose dependent manner, it is sign of sedation. EEHV increase the threshold of MES induced convulsion in a dose dependent manner.

Keywords


Hibiscus vitifolius, PTZ, Maximal electro-shock, Diazepam and Phenytoin

References