Asian Journal of Pharmacy and Technology

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Development and Optimization of Extended-Release Venlafaxine HCl Matrix Tablet


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1 Department of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, India
     

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The purpose of this research was to prepare a extended release drug delivery system of Venlafaxine hydrochloride by using a wax matrix system. The effects of paraffin wax and carnauba wax on drug release profile was investigated. A 32 full factorial design was applied to systemically optimize the drug release profile. Amounts of carnauba wax (X1) and paraffin wax (X2) were selected as independent variables and release after 12 h and time required for 50% (t50) drug release were selected as dependent variables. A mathematical model was generated for each response parameter. Both waxes retarded release after 12 h and increases the t50 but paraffin wax showed significant influence. The drug release pattern for all the formulation combinations was found to be approaching Peppas kinetic model. Suitable combination of two waxes provided fairly good regulated release profile. The response surfaces and contour plots for each response parameter are presented for further interpretation of the results. The optimum formulations were chosen and their predicted results found to be in close agreement with experimental findings.

Keywords

Venlafaxine HCl,Paraffin Wax, Carnauba Wax, Extended Release, Factorial Design, Response Surface
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  • Development and Optimization of Extended-Release Venlafaxine HCl Matrix Tablet

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Authors

Jyotir Patel
Department of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, India

Abstract


The purpose of this research was to prepare a extended release drug delivery system of Venlafaxine hydrochloride by using a wax matrix system. The effects of paraffin wax and carnauba wax on drug release profile was investigated. A 32 full factorial design was applied to systemically optimize the drug release profile. Amounts of carnauba wax (X1) and paraffin wax (X2) were selected as independent variables and release after 12 h and time required for 50% (t50) drug release were selected as dependent variables. A mathematical model was generated for each response parameter. Both waxes retarded release after 12 h and increases the t50 but paraffin wax showed significant influence. The drug release pattern for all the formulation combinations was found to be approaching Peppas kinetic model. Suitable combination of two waxes provided fairly good regulated release profile. The response surfaces and contour plots for each response parameter are presented for further interpretation of the results. The optimum formulations were chosen and their predicted results found to be in close agreement with experimental findings.

Keywords


Venlafaxine HCl,Paraffin Wax, Carnauba Wax, Extended Release, Factorial Design, Response Surface

References