Asian Journal of Pharmacy and Technology

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Assessment of Phase Diagrams by Cut and Weigh Method: A Technical Note


Affiliations
1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi–110062, India
2 Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062, India
     

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A good number of manuscripts are being published where the authors carry out qualitative assessment of the region of interest in the phase diagrams. These qualitative assessments can be sensed as a lack of sound technique for quantitative assessment. In the present technical note we have developed a simple cut and weigh method to offer a quantitative method for assessing phase diagrams. The method was validated and explained using sample analysis. The method was found to be robust, quantitative and enabled statistical comparison of the results. The method was found to be excellent even when applied for samples below a weight of 10 mg and that too on different paper sheets. The suggested technique of expressing the result as a percentage of the total area could offer a universal applicability of the method for assessment of phase diagrams. The developed and validated method would be a great tool for the researchers requiring quantitative assessment of phase diagrams.

Keywords

Nanoemulsion, Microemulsion, Validation, p value
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  • Assessment of Phase Diagrams by Cut and Weigh Method: A Technical Note

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Authors

K. Pramod
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi–110062, India
Shahid H. Ansari
Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062, India
Javed Ali
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi–110062, India

Abstract


A good number of manuscripts are being published where the authors carry out qualitative assessment of the region of interest in the phase diagrams. These qualitative assessments can be sensed as a lack of sound technique for quantitative assessment. In the present technical note we have developed a simple cut and weigh method to offer a quantitative method for assessing phase diagrams. The method was validated and explained using sample analysis. The method was found to be robust, quantitative and enabled statistical comparison of the results. The method was found to be excellent even when applied for samples below a weight of 10 mg and that too on different paper sheets. The suggested technique of expressing the result as a percentage of the total area could offer a universal applicability of the method for assessment of phase diagrams. The developed and validated method would be a great tool for the researchers requiring quantitative assessment of phase diagrams.

Keywords


Nanoemulsion, Microemulsion, Validation, p value

References