Phytochemical Analysis and Comparative Anticonvulsant Activity of Celastrus Paniculatus Willd. Mes Induced Seizure in Mice

The present study evaluated the anticonvulsant potential of petroleum ether and ethanolic extracts seeds of Celastrus paniculatus Willd. On Maximal electroshock and Pentylenetetrazole induce seizures in mice. The extract (petroleum ether and ethanolic) 200 mg/kg, 400 mg/kg, 600 mg /kg were given intraperitonially. The latency of seizures, death time and % mortality were observed. EECP and PECP gave significant protection against MES (Maximal electroshock) and PTZ (pentylenetetrazole) induced convulsion. The p value of PECP in PTZ P < 0.001and MES in PECP P < 0.01, P < 0.001. was statistically significant. Phytochemical Screening of the plant revels the presence of alkaloids, tannins, phenolic compound, fatty acids, steroids and flavonoids. The results indicate a possible efficacy potential of the plant extract of Celastrus paniculatus Willd. in convulsion.