Ultrasound-Promoted Green Synthesis and Pharmacological Screening of Some Novel 4-(3, 5-Diaryl Substituted)-4,5-Dihydro-1H-Pyrazol-1-yl) Benzene Sulfonamide

A simple, efficient and green procedure has been developed for the synthesis of novel of 4-(3, 5-diarylsubstituted)-4,5- dihydro-1H-pyrazol-1-yl) benzene sulfonamides using ultrasonic irradiation. The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times and milder conditions. A mixture of substituted prop-2-en-1-ones, 4-hydrazinylbenzenesulfonamide hydrochloride and hydrazine hydrate in ethanol and acetic acid was irradiated under ultrasound in an open vessel. The synthesized pyrazolines containing benzenesulphonamide group were evaluated for their anti-inflammatory activity using Carrageenan-induced rat hind paw oedema and have shown promising t anti-inflammatory activity.