Determination of Aripiprazole in Bulk Formulation by Visible Spectrophotometric Methods

Two simple, economical, precise and reproducible visible spectrophotmetric methods have been developed for the estimation of aripiprazole in bulk formulation. The developed methods are based on the formation of charge transfer coloured complex of aripiprazole with N-Bromo succinimide and complex with chloramine-T using double distilled water. The complex with N-Bromo succinimide shows absorbance maxima at 520.0 nm and linearity in the concentration range of 1-20 μg/ml. The extracted complex with chloramine-T shows absorbance maxima at 540.0 nm and the linearity in the concentration range of 0.2-0.8 μg/ml. Results of analysis for both the methods were validated statistically and by recovery studies.