Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

CuCl2.2H2O-Catalysed One-Pot Multi-Component Synthesis of β-Acetamido Ketones


Affiliations
1 Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004, Jharkhand, India
     

   Subscribe/Renew Journal


One pot, four-component condensation of an aryl aldehyde, acetyl chloride, acetophenone and acetonitrile in the presence of Copper(II) chloride dihydrate is reported. Copper(II) chloride as an inexpensive, efficient, and readily available catalyst for the synthesis of β-acetamido ketones in high yields. The products obtained were clean and devoid of any undesired impurities as evident from 1H NMR, IR, and TLC analysis.

Keywords

Aryl Aldehyde, Acetyl Chloride, Acetophenone, Copper(II) Chloride, β-Acetamido Ketones.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 230

PDF Views: 0




  • CuCl2.2H2O-Catalysed One-Pot Multi-Component Synthesis of β-Acetamido Ketones

Abstract Views: 230  |  PDF Views: 0

Authors

Rajat S. Pathak
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004, Jharkhand, India
Amiya Shekhar
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004, Jharkhand, India
Devendra D. Pathak
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004, Jharkhand, India

Abstract


One pot, four-component condensation of an aryl aldehyde, acetyl chloride, acetophenone and acetonitrile in the presence of Copper(II) chloride dihydrate is reported. Copper(II) chloride as an inexpensive, efficient, and readily available catalyst for the synthesis of β-acetamido ketones in high yields. The products obtained were clean and devoid of any undesired impurities as evident from 1H NMR, IR, and TLC analysis.

Keywords


Aryl Aldehyde, Acetyl Chloride, Acetophenone, Copper(II) Chloride, β-Acetamido Ketones.