Asian Journal of Research in Chemistry

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Multi-Component Reaction and their Application in Drug Discovery


Affiliations
1 Veerayatan Institute of Pharmacy, Mandvi-Kutch, Gujarat, India
2 R.B. Patel Mahila Pharmacy College, Atkot, Gujarat, India
     

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Multicomponent reactions (MCRs) provide a powerful tool towards the one-pot synthesis of diverse and complex compounds on the one hand and small and 'drug-like' heterocycles on the other hand. No other single synthesis technology enables chemists to search such large chemical spaces as provided by MCRs. This review describes various three component and four component reaction example and recent advances in the application of isocyanide-based multicomponent reactions (IMCRs) in drug discovery.

Keywords

Multicomponent Reaction, Three Component Reaction, Four Component Reaction, Application, Isocyanide Based Reaction.
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  • Multi-Component Reaction and their Application in Drug Discovery

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Authors

Poonam R. Faldu
Veerayatan Institute of Pharmacy, Mandvi-Kutch, Gujarat, India
Sandip K. Dadhaniya
R.B. Patel Mahila Pharmacy College, Atkot, Gujarat, India
Chirag J. Patel
Veerayatan Institute of Pharmacy, Mandvi-Kutch, Gujarat, India
G. Vidyasagar
Veerayatan Institute of Pharmacy, Mandvi-Kutch, Gujarat, India

Abstract


Multicomponent reactions (MCRs) provide a powerful tool towards the one-pot synthesis of diverse and complex compounds on the one hand and small and 'drug-like' heterocycles on the other hand. No other single synthesis technology enables chemists to search such large chemical spaces as provided by MCRs. This review describes various three component and four component reaction example and recent advances in the application of isocyanide-based multicomponent reactions (IMCRs) in drug discovery.

Keywords


Multicomponent Reaction, Three Component Reaction, Four Component Reaction, Application, Isocyanide Based Reaction.