Synthesis of New Indoline-2-Ones and their Microbial Activity

Freddy H. Havaldar; Azadkumar S. Sharma; Peter Roni F. Pinto

Vol 4, No 12 (2011)
Pages: 1840-1843
Published: 2011-12-01

Synthesis of New Indoline-2-Ones and their Microbial Activity

Freddy H. Havaldar , Azadkumar S. Sharma , Peter Roni F. Pinto

Affiliations
1 Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001, India

The acid hydrazides (I and IV) were condensed with indole-2,3-dione in ethanol to yield hydrazono-indolin-2-ones (II and V) which on aminomethylation with formaldehyde and different amines furnished 1-(substituted aminomethyl)-hydrazono-indolin-2-ones (IIIa-e and VIa-e). The structures of the newly synthesized compounds have been confirmed by IR, ¹H NMR and Mass spectra. These compounds have shown promising biological activity.