Asian Journal of Research in Chemistry

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Synthesis and Evaluation of Antioxidant and Anti-Inflammatory Activity of Conjugates of Amino Acids with N-Aroyl-N, N-Dicyclohexyl Urea


Affiliations
1 A.K.R.G. College of Pharmacy, Nallajerla, West Godavari, Andhra Pradesh,-534112, India
2 School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Orissa,-751003, India
     

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A series of 2-((2-3-benzoyl-1,3-dicyclohexylureido)-2-oxoethyl)amino)-3-(4hydroxyphenyl) propanoic acid (3a) and its analogs were synthesized from N,N-Dicyclohexylcarbodiimide (DCC) by acetylating and finally condensing with amino acids to yield good antioxidant molecules which are showing the potency nearer to ascorbic acid and exploring their anti inflammatory activity.

Keywords

Amino Acid, N-Aroyl-N, N-Dicyclohexyl Urea, Antioxidant, DPPH.
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  • Synthesis and Evaluation of Antioxidant and Anti-Inflammatory Activity of Conjugates of Amino Acids with N-Aroyl-N, N-Dicyclohexyl Urea

Abstract Views: 257  |  PDF Views: 0

Authors

Shakti Prasanna Sahoo
A.K.R.G. College of Pharmacy, Nallajerla, West Godavari, Andhra Pradesh,-534112, India
Bharat Bhusan Subudhi
School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Orissa,-751003, India
Rachana Swain
A.K.R.G. College of Pharmacy, Nallajerla, West Godavari, Andhra Pradesh,-534112, India

Abstract


A series of 2-((2-3-benzoyl-1,3-dicyclohexylureido)-2-oxoethyl)amino)-3-(4hydroxyphenyl) propanoic acid (3a) and its analogs were synthesized from N,N-Dicyclohexylcarbodiimide (DCC) by acetylating and finally condensing with amino acids to yield good antioxidant molecules which are showing the potency nearer to ascorbic acid and exploring their anti inflammatory activity.

Keywords


Amino Acid, N-Aroyl-N, N-Dicyclohexyl Urea, Antioxidant, DPPH.