Absorption Correction Method for Estimation of Amlodipine Besylate and Olmesartan Medoxomil in Combined Tablet Dosage Form

A new, simple, accurate and sensitive UV - spectrophotometric absorption correction method has been developed for simultaneous determination of amlodipine besylate and olmesartan medoxomil in combined tablet dosage form. Methanol and distilled water were used as solvents. The wavelengths selected for the analysis were 363nm and 258 nm for amlodipine besylate and olmesartan medoxomil, respectively. Beer's law obeyed the concentration range of 1.25- 6.25 μg/ ml and 5 - 25 μg/ml for amlodipine besylate and olmesartan medoxomil respectively. The method was validated stastically.