Synthesis and Antimicrobial Evaluation of Bisthiazolidinones Built Around Aliphatic Chains

The bisthiazolidinones 3a-3k built around the aliphatic chains ranging from two to twelve carbon units have been synthesized in good yields by refluxing bis-Schiff's bases 2a-2k with ethyl bromoacetate in dioxane medium. The compounds 2a-2k were obtained from the reaction of bisaldehydes 1a-1k with thiosemicabazide in dry EtOH. The length of the internal spacer did not have any significant effect upon the formation and antimicrobial behavior of the bisthiazolidinones 3a-3k. The structures of the new intermediates 2f, 2h and 2j and final compounds 3a-3k have been determined from the rigorous analysis of their IR, ¹H-NMR, ¹³C-NMR, Mass (ESI) and elemental analysis.