Asian Journal of Research in Chemistry

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Development and Validation of Spectrophotometric Method for Quantitative Estimation of Eletriptan Hydrobromide in Bulk and Pharmaceutical Dosage Forms


Affiliations
1 Department of Pharmaceutical Analysis, Bharathi College of Pharmacy, Bharathi Nagara, Mandya (District), Karnataka - 571 422, India
     

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The Simple, precise and economical UV method have been developed and validated for the quantitative for the estimation of Eletriptan hydrobromide in bulk and pharmaceutical dosage forms. Eletriptan hydrobromide is dissolve in the water and It shows absorbance maxima at 219 nm, Beer's law was found to be obeyed in the concentration range of 5-25 μg/mL. The developed method was validated according to ICH guidelines and was found to be accurate and precise. The proposed method can be successfully applied for the estimation of Eletriptan hydrobromide in bulk and pharmaceutical dosage forms. Results of the analysis were validated statistically and by recovery studies.

Keywords

Eletriptan Hydrobromide, UV Spectrophotometry, Zero Order Spectroscopy.
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  • Development and Validation of Spectrophotometric Method for Quantitative Estimation of Eletriptan Hydrobromide in Bulk and Pharmaceutical Dosage Forms

Abstract Views: 247  |  PDF Views: 0

Authors

R. Venkatamahesh
Department of Pharmaceutical Analysis, Bharathi College of Pharmacy, Bharathi Nagara, Mandya (District), Karnataka - 571 422, India
N. Amith
Department of Pharmaceutical Analysis, Bharathi College of Pharmacy, Bharathi Nagara, Mandya (District), Karnataka - 571 422, India
K. Sireesha
Department of Pharmaceutical Analysis, Bharathi College of Pharmacy, Bharathi Nagara, Mandya (District), Karnataka - 571 422, India
M. Balaji
Department of Pharmaceutical Analysis, Bharathi College of Pharmacy, Bharathi Nagara, Mandya (District), Karnataka - 571 422, India
S. Raja
Department of Pharmaceutical Analysis, Bharathi College of Pharmacy, Bharathi Nagara, Mandya (District), Karnataka - 571 422, India

Abstract


The Simple, precise and economical UV method have been developed and validated for the quantitative for the estimation of Eletriptan hydrobromide in bulk and pharmaceutical dosage forms. Eletriptan hydrobromide is dissolve in the water and It shows absorbance maxima at 219 nm, Beer's law was found to be obeyed in the concentration range of 5-25 μg/mL. The developed method was validated according to ICH guidelines and was found to be accurate and precise. The proposed method can be successfully applied for the estimation of Eletriptan hydrobromide in bulk and pharmaceutical dosage forms. Results of the analysis were validated statistically and by recovery studies.

Keywords


Eletriptan Hydrobromide, UV Spectrophotometry, Zero Order Spectroscopy.