Asian Journal of Research in Chemistry

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Zinc Sulfamate Catalysed Synthesis of Trisubstituted Imidazole


Affiliations
1 Reserch Lab of Pure and Applied Chemistry, Maharashtra Mahavidhyalaya, Nilanga, Dist: Latur, India
2 Department of Chemistry, K M C College, Khopoli, Dist Raigad, India
3 Department of Chemistry, S. M. P. College, Murum, Omerga, Dist: Osmanabad, India
4 Department of Chemistry, Shivneri Mahavidhyalaya, Shirur, Anantpal, Dist Latur, India
5 Department of Chemistry, Rajshri Shahu Mahavidhyalaya, Latur, India
     

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Numerous imidazole derivatives are reported as pharmacological agents like azomycin, clotrimazole, Miconazole, ergothionine, clonidine and moxonidine. One of the most important applications of imidazoles derivatives are treatment for denture and cancer therapy. Imidazoles are in general, well known to possess, anti-cancer activity. These compounds are 5 membered planar ring, soluble in water and other polar solvents. Radziszewski and Jaapproposed the first synthesis of the imidazole corein 1882, starting from 1,2-dicarbonyl compounds, aldehydes and ammonia to obtain 2,4,5-triphenylimidazole [1, 2].

Keywords

Imidazole, Zinc Sulphate, Trisubstitution etc.
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  • Zinc Sulfamate Catalysed Synthesis of Trisubstituted Imidazole

Abstract Views: 287  |  PDF Views: 2

Authors

Jairaj K. Dawle
Reserch Lab of Pure and Applied Chemistry, Maharashtra Mahavidhyalaya, Nilanga, Dist: Latur, India
V. B. Suryawanshi
Department of Chemistry, K M C College, Khopoli, Dist Raigad, India
S. R. Mathapati
Department of Chemistry, S. M. P. College, Murum, Omerga, Dist: Osmanabad, India
A. S. Bondge
Department of Chemistry, Shivneri Mahavidhyalaya, Shirur, Anantpal, Dist Latur, India
K. I. Momin
Department of Chemistry, Rajshri Shahu Mahavidhyalaya, Latur, India

Abstract


Numerous imidazole derivatives are reported as pharmacological agents like azomycin, clotrimazole, Miconazole, ergothionine, clonidine and moxonidine. One of the most important applications of imidazoles derivatives are treatment for denture and cancer therapy. Imidazoles are in general, well known to possess, anti-cancer activity. These compounds are 5 membered planar ring, soluble in water and other polar solvents. Radziszewski and Jaapproposed the first synthesis of the imidazole corein 1882, starting from 1,2-dicarbonyl compounds, aldehydes and ammonia to obtain 2,4,5-triphenylimidazole [1, 2].

Keywords


Imidazole, Zinc Sulphate, Trisubstitution etc.