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Microwave Assisted Synthesis, Spectral Studies and Biological Evaluation of Some Benzimidazole Derivatives


Affiliations
1 Dept. of Chemistry, College of Science, University of Basrah, Basrah, Iraq
     

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Benzimidazole (A) was synthesis by reaction of phenylenediamine with 4-p-amino benzaldehyde and then Schiff base synthesis by reaction amino benzimidazole with terphthaldehyde. Azetidinone (C) and Thaizolidinone (D) were also synthesized by reaction benzimidazole Schiff base with acetyl chloride and mercpto acetic acid respectively. These compounds have been synthesis by microwave irridation and characterized by M.P., TLC, CHN, UV, FT-IR, 1HNMR, and 13CNMR. The biological screening data of the synthesized compounds were also studied.

Keywords

Microwave, Benzimidazole, Schiff Base, Azetidinone, Thaizolidinone, Anti-Bacterial.
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  • Microwave Assisted Synthesis, Spectral Studies and Biological Evaluation of Some Benzimidazole Derivatives

Abstract Views: 209  |  PDF Views: 2

Authors

Zeki A. Naser Al-Shamkhani
Dept. of Chemistry, College of Science, University of Basrah, Basrah, Iraq

Abstract


Benzimidazole (A) was synthesis by reaction of phenylenediamine with 4-p-amino benzaldehyde and then Schiff base synthesis by reaction amino benzimidazole with terphthaldehyde. Azetidinone (C) and Thaizolidinone (D) were also synthesized by reaction benzimidazole Schiff base with acetyl chloride and mercpto acetic acid respectively. These compounds have been synthesis by microwave irridation and characterized by M.P., TLC, CHN, UV, FT-IR, 1HNMR, and 13CNMR. The biological screening data of the synthesized compounds were also studied.

Keywords


Microwave, Benzimidazole, Schiff Base, Azetidinone, Thaizolidinone, Anti-Bacterial.