A Validated Non-Aqueous Potentiometric Titration Method for Quantitative Determination of Alprazolam from Pharmaceutical Preparation

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of alprazolam from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r² > 0.9999 ) between 20 % to 100 % of 0.100 mg of drug substance weight. The percentage recovery of alprazolam in the optimized method was between 100.0 to 100.416 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.