Convenient, Rapid Microwave Assisted Synthesis of Some Novel Imidazole Derivatives and their Antimicrobial Activity

A series of imidazole derivatives were synthesized by condensation of, differently substituted 4-benzylidene-2- phenyloxazol-5(4H)-one and ammonia, which on further reaction with barbituric acid produces the final products (substituted 5-((5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-4-yl)methyl)pyrimidine-2,4,6(1H,3H,5H)-triones) 3(a-f). The structures of the newly synthesized compounds were supported by IR, ¹H NMR, ¹³C NMR and MASS spectral data. All the reactions were carried out by environmental benign, efficient and extremely fast procedure microwave assisted synthesis. The derivatives of these moieties were screened for antibacterial and antifungal activity. It was seen that the compounds showed more antibacterial activity towards the test organisms S. pyogenus and S. aureus and significant activity against all strains of fungi.