Synthesis, Characterization, Thermal and Antibacterial Studies of Organosilicon (IV) and Organotin (IV) Complexes Derived from Schiff Base Ligand

The aim of the present work is to evaluate the biological activities of silicon and tin complexes with Schiff base ligand derived from 4-nitro-o-phenylenediamine and dehydroacetic acid in 1:1 molar ratio. Schiff base and their complexes have been characterized by elemental analysis, FT-IR and NMR (¹H, ¹³C, ²⁹Si, ¹¹⁹Sn) spectral techniques. On the basis of analysis penta-coordinated geometry around silicon and tin atom in 1:1 molar ratio was proposed. Thermal studies of all the synthesized complexes have been carried out using thermogravimetry (TG) technique under a nitrogen atmosphere. The thermal decompositions occurred in two steps and resulted into the formation of pure SiO₂ and SnO₂ residue. The biological activity of Schiff base ligand as well as their complexes has been carried out by minimum inhibitory concentration of tested compounds against various bacterial strains (S.epidermidis, S.hominis, P.aeruginosa and K.pneumoniae) which was later compared with standard drug ciprofloxacin. The antibacterial data revealed that complexes shows superior biological activity as compared to their respective ligand.