Asian Journal of Research in Chemistry

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Validated UV-Spectroscopic Estimation of Simvastatin Concentration in Bulk and Dosage Form


Affiliations
1 Department of Pharmacy, Pacific University, Udaipur, Rajasthan-313003, India
2 Department of Quality Assurance Techniques, KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, India
     

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A simple, accurate, precise, and sensitive a highly selective ultra violet spectrophotometric method has been developed for the estimation of drug in bulk and dosage form. It shows maximum absorbance at 238nm. The Beer-Lambert's law was obeyed in the concentration range of 5-35μg/ml. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor for Simvastatin. The percentage recovery was found to be within range. Thus method was successfully applied for routine analysis of Simvastatin in bulk drug and dosage form.

Keywords

Simvastatin, UV-Method, Spectrometric Method, Determination.
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  • Validated UV-Spectroscopic Estimation of Simvastatin Concentration in Bulk and Dosage Form

Abstract Views: 277  |  PDF Views: 2

Authors

Pramod Nanasaheb Katkade
Department of Pharmacy, Pacific University, Udaipur, Rajasthan-313003, India
Ravindranath Bhanudas Saudagar
Department of Quality Assurance Techniques, KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, India

Abstract


A simple, accurate, precise, and sensitive a highly selective ultra violet spectrophotometric method has been developed for the estimation of drug in bulk and dosage form. It shows maximum absorbance at 238nm. The Beer-Lambert's law was obeyed in the concentration range of 5-35μg/ml. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor for Simvastatin. The percentage recovery was found to be within range. Thus method was successfully applied for routine analysis of Simvastatin in bulk drug and dosage form.

Keywords


Simvastatin, UV-Method, Spectrometric Method, Determination.