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Biodiversity of Oxazolone Derivatives in Medicinal Chemistry:A Review
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There has been keen interest in the development of novel compounds with antimicrobial, analgesic, antiinflammatory, anticancer, anti-HIV, antiangiogenic, anticonvulsant, antitumor, antagonistic and cardiotonic activity. Oxazolone, a five membered heterocyclic nucleus is a versatile lead compound for designing potent medicinally active agents. This review represents the diverse biological applications of oxazolone and their excellent performance as a substrate in the synthesis of various heterocyclic bioactive compounds, which fascinates the medicinal chemists to pursue research on this nucleus.
Keywords
Erlenmeyer Reaction, Diels-Alder Reaction, Azlactone, Antimicrobial Activity.
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