Asian Journal of Research in Chemistry

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Preparation and Evaluation of Anti-Inflammatory Transdermal Drug Delivery System


Affiliations
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, India
2 B.N.B.Swaminarayan College of Pharmacy, Vapi, Gujrat, India
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), India
4 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, India
5 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India
     

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An abundance of the anti-inflammatory drugs are available for use in current medicine which have an established use in the treatment of arthritis and other painful conditions, amongst them one of the novel drug is Aceclofenac. Gels are an excellent formulation for several routes of administration such as oral, topical, nasal, vaginal, and rectal. Gel can be clear formulations when all of the particles completely dissolve in the dispersing medium. But this doesn't occur in all gels, and some are therefore turbid. This need has emphasized the importance of developing a topical dosage form of such drugs.

Aceclofenac is novel non steroidal anti-inflammatory drug which have proven its effectiveness in many of painful diseased conditions like osteoarthritis, rheumatoid arthritis, spondylitis etc. Like other NSAIDs it is also associated with adverse effects, majority of them are of gastrointestinal system (dyspepsia, abdominal pain, nausea and diarrhea). Present study was undertaken to develop an effective and stable topical formulations of Aceclofenac gel.


Keywords

TDDS, Aceclofenac.
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  • Preparation and Evaluation of Anti-Inflammatory Transdermal Drug Delivery System

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Authors

S. M. Sarode
Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, India
A. R. Bendale
B.N.B.Swaminarayan College of Pharmacy, Vapi, Gujrat, India
M. Mittal
Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, India
M. A. Chaudhri
K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), India
M. K. Kale
K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), India
G. Vidyasagar
Veerayatan Institute of Pharmacy, Bhuj, Gujrat, India
B. Shrivastava
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India

Abstract


An abundance of the anti-inflammatory drugs are available for use in current medicine which have an established use in the treatment of arthritis and other painful conditions, amongst them one of the novel drug is Aceclofenac. Gels are an excellent formulation for several routes of administration such as oral, topical, nasal, vaginal, and rectal. Gel can be clear formulations when all of the particles completely dissolve in the dispersing medium. But this doesn't occur in all gels, and some are therefore turbid. This need has emphasized the importance of developing a topical dosage form of such drugs.

Aceclofenac is novel non steroidal anti-inflammatory drug which have proven its effectiveness in many of painful diseased conditions like osteoarthritis, rheumatoid arthritis, spondylitis etc. Like other NSAIDs it is also associated with adverse effects, majority of them are of gastrointestinal system (dyspepsia, abdominal pain, nausea and diarrhea). Present study was undertaken to develop an effective and stable topical formulations of Aceclofenac gel.


Keywords


TDDS, Aceclofenac.