A New Simple RP-HPLC Method for Simultaneous Estimation of Asprin, Atorvastatin and Clopidogrel in Capsule Dosage Form

The working conditions for the high pressure liquid Chromatography method was established for Asprin, Atorvastatin and Clopidogrel and then applied on pharmaceutical dosage forms. A rapid sensitive of Chromarographic separation was accomplished using hypersil BDS C₁₈ (250×4.6 mm, 5μ) analytical column with mobile phase consisting of, acetonitrile, water (p^H 3)and methanol (50:40:10 v/v). The eluent were detected by UV absorbance at 248 nm. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification and solution stability. The proposed method can be used for the estimation of these drugs in combined pharmaceutical dosage forms.