Novel Spectrophotometric Estimation of Naproxen Tablet Formulations Using Sodium Citrate as Hydrotropic Solubilizing Agent

Hydrotropy is one of the solubilizing techniques to enhance the solubility of poorly water soluble drugs. In the present investigation, hydrotropic solution of sodium citrate (0.1M) was employed as solubilizing agent to solubilize the poorly water soluble drug Naproxen fine powder and its tablet dosage form for spectrophotometric determination in UV region. Naproxen shows maximum absorbance at 330 nm and follows Beer's law in concentration range of 20-140 mcg/mL. Results of analysis were statistically validated for the linearity, precision, LOD, and LOQ. The proposed method is new, simple, accurate, reliable, more economic and can be successfully employed in routine to analyze Naproxen tablets. Either hydrotropic agent or commonly used tablet additives did not interference in analysis. The percentage recovery was within the range between 99 and 100.