Synthesis of N4 Donor Novel Schiff Base Ligands and their Co(II), Ni(II), Cu(II), Rh(III) and Pd(II) Metal Complexes for Biological Studies and Catalytic Oxidation on Drug Molecule

Novel Schiff base ligands (N4 donor; L1-L2) have been derived from the condensation of O- phthalaldehyde (OPA) with some substituted aromatic amines, and subsequently used to synthesize the metal complexes of Co(II), Ni(II), Cu(II), Rh(III) and Pd(II). The structures of Schiff base ligands and their metal complexes were characterized by elemental analyses, IR, 1H and 13CNMR, mass and electronic spectroscopy, thermal, magnetic and conductance measurements. Both the ligands and their complexes have been screened for their antibacterial activities against Gram positive and Gram negative bacteria by MIC method and antifungal activities against Aspergillus flavus and Fusarium oxysporum. Further, these metal complexes have been investigated as catalysts in the oxidation of pharmaceutical drug didanosine. The oxidized products have further been treated with sulphanilic acid to develop the colored products to determine by spectrophotometrically. The current oxidation method is an environmentally friendly, simple to set-up, requires short reaction time, produces high yield and does not require co-oxidant.