Kinetic Estimation of Ibuprofen and Nimesulide in Pharmaceuticals

Simple Kinetic Spectrophotometric methods have been developed and validated for the estimation of Anti inflammatory drugs, namely Ibuprofen and Nimesulide in pharmaceutical dosage forms. The method is based on the oxidation of Ibuprofen and Nimesulide with alkaline potassium permanganate. In alkaline medium permanganate (Mn⁺⁷) oxidizes Ibuprofen and Nimesulide undergoes one electron reduction to give a green colored manganate ions (Mn⁺⁶) which has wavelength maximum at 610 nm, and unreacted permanganate at 526 nm. The Fixed time (at 240 sec) and Rate constant method were utilized for constructing the calibration graphs. The calibration graphs are linear in the concentration ranges from 30.8–308 gmL⁻¹ and 20.6 – 206 gmL⁻¹ using the Fixed time methods and Rate constant methods respectively. The results are validated statistically and checked through recovery studies. The method has been successfully applied for the determination of the studied Anti inflammatory drugs in commercial dosage forms.