Asian Journal of Research in Chemistry

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Comparison of Photodynamic Activities of Ag@Tio2 and Au@Tio2 Core-Shell Nanoparticles in Human Erythrocytes


Affiliations
1 Department of Chemistry, Queen Mary’s College, Chennai, India
2 Department of Chemistry, Adhiparasakthi College of Science, Kalavai, India
3 Department of Physics, Anna University, Chennai, India
     

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Core-shell type nanoparticles namely Ag@TiO2 and Au@TiO2 were prepared by one pot simultaneous reduction of HAuCl4 and hydrolysis of Ti(IV) isopropoxide. They were characterized by absorption and fluorescence spectroscopy, XRD, HR-TEM and AFM techniques. XRD patterns show the presence of anatase form of TiO2 and the noble metals. Since the catalytic properties of the oxide surfaces modified with the metal core especially photo catalysis is an important aspect and considering the fact that erythrocytes serve as model cells to the molecular mechanism of PDT, the photohemolysis was studied using these core-shell type NPs viz. Ag@TiO2 and Au@TiO2. Their photodynamic activities were compared. The effect of scavengers viz., GSH and NaN3 showed that there is a considerable amount of reactive oxygen species formation which are responsible for cell death. The detailed mechanism has been discussed.


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  • Comparison of Photodynamic Activities of Ag@Tio2 and Au@Tio2 Core-Shell Nanoparticles in Human Erythrocytes

Abstract Views: 224  |  PDF Views: 1

Authors

Karunakaran Sulochana Meena
Department of Chemistry, Queen Mary’s College, Chennai, India
Thyagarajan Venkataraman
Department of Chemistry, Adhiparasakthi College of Science, Kalavai, India
Prakasa Rao Aruna
Department of Physics, Anna University, Chennai, India
Singaravel Ganesan
Department of Physics, Anna University, Chennai, India

Abstract


Core-shell type nanoparticles namely Ag@TiO2 and Au@TiO2 were prepared by one pot simultaneous reduction of HAuCl4 and hydrolysis of Ti(IV) isopropoxide. They were characterized by absorption and fluorescence spectroscopy, XRD, HR-TEM and AFM techniques. XRD patterns show the presence of anatase form of TiO2 and the noble metals. Since the catalytic properties of the oxide surfaces modified with the metal core especially photo catalysis is an important aspect and considering the fact that erythrocytes serve as model cells to the molecular mechanism of PDT, the photohemolysis was studied using these core-shell type NPs viz. Ag@TiO2 and Au@TiO2. Their photodynamic activities were compared. The effect of scavengers viz., GSH and NaN3 showed that there is a considerable amount of reactive oxygen species formation which are responsible for cell death. The detailed mechanism has been discussed.