Asian Journal of Research in Chemistry

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RP-HPLC Method for the Estimation of Atorvastatin Calcium in Bulk and Pharmaceutical Formulations


Affiliations
1 Hindu College of Pharmacy, Amaravathi Road, Guntur – 522 002, Andhra Pradesh, India
2 DCRM Pharmacy College, Inkollu, Andhra Pradesh, India
3 Siddhartha Institute of Pharmacy, Sattenapalli, Andhra Pradesh, India
     

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The present work describes a simple reverse phase HPLC method for the estimation of Atorvastatin calcium in bulk and pharmaceutical formulations. The estimation was carried out on phenomenex C18 (250 × 4.6 mm, 5μ) column using a mobile phase containing of Acetonitrile: Ortho-phosphoric acid (0.1%): Tetrahydrofuran (48:0.04:52). The eluent was monitored at 244 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.


Keywords

HPLC, Validation, Atorvastatin Calcium and Pharmaceutical Formulation.
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  • RP-HPLC Method for the Estimation of Atorvastatin Calcium in Bulk and Pharmaceutical Formulations

Abstract Views: 246  |  PDF Views: 1

Authors

P. Nagaraju
Hindu College of Pharmacy, Amaravathi Road, Guntur – 522 002, Andhra Pradesh, India
B. Sridhar
DCRM Pharmacy College, Inkollu, Andhra Pradesh, India
P. Jitendra Kumar
Siddhartha Institute of Pharmacy, Sattenapalli, Andhra Pradesh, India
U. Upendra Rao
Hindu College of Pharmacy, Amaravathi Road, Guntur – 522 002, Andhra Pradesh, India
K. Hanumantha Rao
DCRM Pharmacy College, Inkollu, Andhra Pradesh, India
P. N. V. Gopal
Hindu College of Pharmacy, Amaravathi Road, Guntur – 522 002, Andhra Pradesh, India

Abstract


The present work describes a simple reverse phase HPLC method for the estimation of Atorvastatin calcium in bulk and pharmaceutical formulations. The estimation was carried out on phenomenex C18 (250 × 4.6 mm, 5μ) column using a mobile phase containing of Acetonitrile: Ortho-phosphoric acid (0.1%): Tetrahydrofuran (48:0.04:52). The eluent was monitored at 244 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.


Keywords


HPLC, Validation, Atorvastatin Calcium and Pharmaceutical Formulation.