Synthesis and Evaluation of Substituted Imidazolones for Antibacterial and Antioxidant Activities

A series of 4-(substituted benzylidene)-1-(5-phenyl-1,3,4-thiadiazol-2-yl)-2-phenyl -1H-imidazol-5(4H)-ones were synthesized by condensation of 4-benzylidene-2-phenyl-oxazol-5-one with 2-amino-5-phenyl-1,3,4-thiadiazoles in presence of sodium acetate in glacial acetic acid. The intermediate 4-benzylidene-2-phenyl-oxazol-5-ones were prepared by condensing benzaldehydes with benzoyl glycine in presence of acetic anhydride and sodium acetate. The chemical structures of synthesized compounds were confirmed by means of IR, ¹H NMR. All the compounds (10-18) were screened for antibacterial and antioxidant activities. Among all, the compounds 12, 16 exhibited highest antibacterial activity against all the four strains. Compound 12 exhibited highest nitric oxide scavenging activity and most of these compounds showed significant DPPH scavenging activity.