Asian Journal of Research in Chemistry

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Green Synthesis of Isoxazolidines:One Pot Facile Cycloaddition Reactions of Novel N-Phenyl-α-Amino Nitrone in Water


Affiliations
1 Organic Chemistry Laboratory, Sikkim Government College, Gangtok, Sikkim 737 102, India
     

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Novel N-phenyl-α-amino nitrone has been synthesized from formamide and one pot facile 1,3-Dipolar cycloaddition reactions of the nitrone have been studied in water at room temperature in the stereoselective synthesis of novel isoxazolidine derivatives. Significant rate acceleration, changes in stereoselectivity and high yield of these reactions are observed in water compared to organic solvents.


Keywords

N-phenyl-α-Amino Nitrone, Cycloaddition Reaction, Stereoselectivity, Aqueous Phase.
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  • Green Synthesis of Isoxazolidines:One Pot Facile Cycloaddition Reactions of Novel N-Phenyl-α-Amino Nitrone in Water

Abstract Views: 221  |  PDF Views: 1

Authors

Bhaskar Chakraborty
Organic Chemistry Laboratory, Sikkim Government College, Gangtok, Sikkim 737 102, India
Neelam Rai
Organic Chemistry Laboratory, Sikkim Government College, Gangtok, Sikkim 737 102, India

Abstract


Novel N-phenyl-α-amino nitrone has been synthesized from formamide and one pot facile 1,3-Dipolar cycloaddition reactions of the nitrone have been studied in water at room temperature in the stereoselective synthesis of novel isoxazolidine derivatives. Significant rate acceleration, changes in stereoselectivity and high yield of these reactions are observed in water compared to organic solvents.


Keywords


N-phenyl-α-Amino Nitrone, Cycloaddition Reaction, Stereoselectivity, Aqueous Phase.