Synthesis, Characterization and Antimicrobial Activity of Some Synthesised Isoxazole and Pyrazole Derivatives

In the development of organic therapeutic agents, pharmaceutical scientists have explored numerous approaches in finding and developing organic compounds that is now available to us in dosage forms for the treat diseases and often for the maintenance of good health. The present work deals with synthesis of some new isoxazole and Pyrazole derivatives which obtained by reaction takes place between the chemicals hydroxyl amine hydrochloride and hydrazine hydrate with synthesized Chalcones (by Claisen-Schmidt condensation) in a refluxing ethanolic medium in alkali condition. The structures for the synthesized compounds are established by FT-IR, ¹H NMR and elemental analysis later all compounds were evaluated for antimicrobial activity by zone of inhibition. Significant to moderate results are obtained from the compounds.