Asian Journal of Research in Chemistry

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Synthesis and Antimicrobial Activity of Some New 2, 4, 6 -Trisubstituted Pyrimidines


Affiliations
1 Department of Pharmacy, Acharya Nagarjuna University, Guntur - 521250, India
2 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530003, India
3 Centre for Pharmaceutical Sciences, J N T University, Hyderabad – 500085, India
     

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A variety of 2-amino-4-(3'-methyl-4'-hydroxyphenyl)-6-(substituted) pyrimidines were synthesized by reacting various chalcones with guanidine hydrochloride. The required chalcones were prepared by condensation of 3'-methyl-4'- hydroxyacetophenone with various substituted aromatic / heteroaromatic aldehydes in the presence of alkali. All these compounds were characterized by IR, 1H NMR and Elemental analysis. The newly synthesized compounds were evaluated for their antimicrobial activity and some of them have shown significant activity when compared with the standard.


Keywords

Pyrimidines, Synthesis, Antimicrobial Activity.
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  • Synthesis and Antimicrobial Activity of Some New 2, 4, 6 -Trisubstituted Pyrimidines

Abstract Views: 298  |  PDF Views: 1

Authors

N. Srinath
Department of Pharmacy, Acharya Nagarjuna University, Guntur - 521250, India
Y. Rajendra Prasad
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530003, India
K. Mukkanti
Centre for Pharmaceutical Sciences, J N T University, Hyderabad – 500085, India
N. K. Agarwal
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530003, India

Abstract


A variety of 2-amino-4-(3'-methyl-4'-hydroxyphenyl)-6-(substituted) pyrimidines were synthesized by reacting various chalcones with guanidine hydrochloride. The required chalcones were prepared by condensation of 3'-methyl-4'- hydroxyacetophenone with various substituted aromatic / heteroaromatic aldehydes in the presence of alkali. All these compounds were characterized by IR, 1H NMR and Elemental analysis. The newly synthesized compounds were evaluated for their antimicrobial activity and some of them have shown significant activity when compared with the standard.


Keywords


Pyrimidines, Synthesis, Antimicrobial Activity.