Asian Journal of Research in Chemistry

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Spectrophotometric Methods for the Determination of Milnacipran


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1 K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada -520010, A.P., India
     

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Two simple and sensitive spectrophotometric methods have been developed for the estimation of Milnacipran in pure and pharmaceutical dosage forms. Method A is based on oxidative coupling of the drug with folin-ciocaltaeu reagent (F.C.reagent) λmax 780nm. Method B is based on oxidation followed by complex formation when the drug reacts with P-Methylamino phenolsulphate (Metol reagent) λmax 540nm. The absorbance of the colored species is measured against the corresponding reagent blank. These methods have been statistically evaluated and found to be precise and accurate.


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  • Spectrophotometric Methods for the Determination of Milnacipran

Abstract Views: 270  |  PDF Views: 1

Authors

P. Sai Praveen
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada -520010, A.P., India
M. Shaiba
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada -520010, A.P., India
S. K. Rasool
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada -520010, A.P., India
T. Srinivasa Rao
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada -520010, A.P., India
D. Prasad Babu
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada -520010, A.P., India

Abstract


Two simple and sensitive spectrophotometric methods have been developed for the estimation of Milnacipran in pure and pharmaceutical dosage forms. Method A is based on oxidative coupling of the drug with folin-ciocaltaeu reagent (F.C.reagent) λmax 780nm. Method B is based on oxidation followed by complex formation when the drug reacts with P-Methylamino phenolsulphate (Metol reagent) λmax 540nm. The absorbance of the colored species is measured against the corresponding reagent blank. These methods have been statistically evaluated and found to be precise and accurate.