Asian Journal of Research in Chemistry

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Synthesis, Characterization and Antimicrobial Activity of A 5(4-(4- Substituted)Aminobenzylidine)Thiazolidine-2,4-Dione Derivatives


Affiliations
1 Ultra College of Pharmacy, Madurai (T.N), India
2 Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), India
     

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A novel 5(4-(4-substituted)Aminobenzylidine)thiazolidine-2,4-dione derivatives were synthesized and characterized by IR and H-NMR spectral analysis. Antibacterial and antifungal activities of the compounds were assessed by in vitro growth inhibitory activity against Escherichia coli, Staphylococcus aureus, Asperigillus niger, Candida albicans by using the disc diffusion method. Most of all compounds exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli, while weak antifungal activity against Asperigillus niger and Candida albicans.


Keywords

Thiazolidine-2,4-dione, Antibacterial and Antifungal Activity, Disc Diffusion Method.
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  • Synthesis, Characterization and Antimicrobial Activity of A 5(4-(4- Substituted)Aminobenzylidine)Thiazolidine-2,4-Dione Derivatives

Abstract Views: 234  |  PDF Views: 1

Authors

Suresh Rajput
Ultra College of Pharmacy, Madurai (T.N), India
Dharamveer Sisodia
Ultra College of Pharmacy, Madurai (T.N), India
Hemant Badwaik
Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), India
Deepa Thakur
Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), India
Kushagra Nagori
Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), India

Abstract


A novel 5(4-(4-substituted)Aminobenzylidine)thiazolidine-2,4-dione derivatives were synthesized and characterized by IR and H-NMR spectral analysis. Antibacterial and antifungal activities of the compounds were assessed by in vitro growth inhibitory activity against Escherichia coli, Staphylococcus aureus, Asperigillus niger, Candida albicans by using the disc diffusion method. Most of all compounds exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli, while weak antifungal activity against Asperigillus niger and Candida albicans.


Keywords


Thiazolidine-2,4-dione, Antibacterial and Antifungal Activity, Disc Diffusion Method.