Asian Journal of Research in Chemistry

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Simultaneous Determination of Ramipril and Hydrochlorothiazide from their Binary Mixture


Affiliations
1 Pharmaceutical Quality Assurance Laboratory, Pharmacy Department, The Maharaja Sayajirao University of Baroda, Vadodara-390001, Gujarat, India
2 Baroda College of Pharmacy, P.O. Limda, Ta. Waghodia, Dist. Vadodara, Pin 391 760, India
     

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Specific, accurate, precise and simple ratio spectra 1st derivative spectrophotometric method was developed for simultaneous determination of HCTZ and RMPL from their binary mixture. For ratio spectra derivative spectrophotometry, the amplitudes were measured at 210.6 for RMPL and the difference in amplitudes at 224.7 and 231 nm were measured for the determination of HCTZ. Commercial tablet formulations and laboratory prepared mixtures were successfully analyzed using the developed methods.

Keywords

Ramipril, Hydrochlorothiazide, Ratio-Spectra.
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  • Simultaneous Determination of Ramipril and Hydrochlorothiazide from their Binary Mixture

Abstract Views: 242  |  PDF Views: 1

Authors

R. Sahu
Pharmaceutical Quality Assurance Laboratory, Pharmacy Department, The Maharaja Sayajirao University of Baroda, Vadodara-390001, Gujarat, India
V. B. Patel
Baroda College of Pharmacy, P.O. Limda, Ta. Waghodia, Dist. Vadodara, Pin 391 760, India
M. Bapna
Baroda College of Pharmacy, P.O. Limda, Ta. Waghodia, Dist. Vadodara, Pin 391 760, India

Abstract


Specific, accurate, precise and simple ratio spectra 1st derivative spectrophotometric method was developed for simultaneous determination of HCTZ and RMPL from their binary mixture. For ratio spectra derivative spectrophotometry, the amplitudes were measured at 210.6 for RMPL and the difference in amplitudes at 224.7 and 231 nm were measured for the determination of HCTZ. Commercial tablet formulations and laboratory prepared mixtures were successfully analyzed using the developed methods.

Keywords


Ramipril, Hydrochlorothiazide, Ratio-Spectra.