Role of Bio-Metal Zn (II) in Anticancer Behaviour of Tamoxifen

Physicochemical, microbial and Pharmacological studies on Zn (II)-Tamoxifen complex have been done in solid and aqueous phase. On the basis of elemental analysis, polarographic studies, amperometric titrations and IR spectral studies the probable formula of the complex has been worked out to be 1:1 Zn (II)-Tamoxifen. The metal ligand interaction has been studied using polarographic method at 25±1°C and at ionic strength of μ=1.0 [KCl].

Microbial studies on the complex were done against various pathogenic bacteria viz. Pseudomonas mangiferae, Staphylococus aureus, Salmonella typhi and Vibreo colarae and fungi i.e. Trichothesium and Chrysosporium sp. using Raper's method. The results indicated increased toxicity of the metal drug complex against bacteria and fungi, understudy.

Mouse Sarcoma Cell line-180 and Balb/C mice were used for the anticancer screening of solid complex in-vitro and in-vivo respectively the result of pharmacological studies with the Metal: Drug complex revealed that the complex more potent as compared to the pure drug regards to its anticancer activity. As such tamoxifen complex may be recommended to the therapeutic experts for its possible use as more potent anticancer drug.