New UV-Visible Spectrophotometric Methods for the Determination of Aripiprazole in Bulk and Pharmaceutical Formulation

A simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method F) are developed for the determination of Aripiprazole (ARIP) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Aripiprazole (ARIP) with 3-Methyl-2-benzo thiazolinone hydrazone (MBTH) and Cerric Ammonium Sulphate (CAS). Method B is based on the formation of colored species on treatment of Aripiprazole (ARIP) with Fecl₃ and 1,10 PTL. Method C is based on the formation of colored species on treatment of Aripiprazole (ARIP) with Folin-Ciocalteu reagent in presence of 4% NaOH Solution. Method D is based on the formation of colored species on treatment of Aripiprazole (ARIP) with DCQC (2,6-dichloroquinone N-chlorimide, Gibbs Reagent). Method E is based on the formation of colored species on treatment of Aripiprazole (ARIP) with NQS (1,2-napthaquinone-4-sulphonic acid). Method F represents UV Spectrophotometric determination of Aripiprazole (ARIP) and its dosage forms in pH 3.0 Buffer:Acetonitrile (62:38v/v) at 250 nm.