Spectrophotometric Determination of Nadolol in Bulk and Pharmaceutical Formulations

Rapid, simple and sensitive spectrophotometric method has been developed for the determination of Nadolol in pharmaceutical bulk and tablet dosage forms. Method is based on the reaction of Nadolol with Sodium Nitropruside, Hydroxyl amine and sodium carbonate, to form light green colored chromogen. The colored species has absorption maximum at 440 nm and obeys Beer's law in the concentration range of 0.1-0.3 mg/ml. The optimum experimental parameters for the experiment have been studied. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. Statistical analysis of the results has been carried out revealing high accuracy and good precision.