Conventional and Microwave-Assisted Synthesis of 5-Halogeno-(X) 2, 4-(1H, 3H) Pyrimidinedione and their Biological Evaluation

A series of 5-halogen substituted 2, 4-(1H, 3H) Pyrimidinedione compounds have been synthesized by an effective, rapid microwave assisted method. The structures of compounds have been elucidated with UV, FTIR, GC-Mass spectrometer, solubility and melting points of compounds were determined. The antibacterial, antifungal and antiviral screening against B.subtilis, S.aureus, E.coli, A.nigar, A.flavus and ND virus revealed their significant activities.

Where, X = F, Cl, Br, I.